Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare disease characterized by single or multiple angiomatous lesions typically located on the scalp and the face. We present a retrospective analysis of 9 cases of ALHE. The lesions appeared largely as multiple grouped papules or, in some cases, subcutaneous nodules, located mainly on the scalp, particularly around the ear. We also observe...

Purpose: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare disorder presenting with solitary or multiple nodules in the dermis or subcutaneous tissues. ALHE shares clinical as well as histopathological characteristics with Kimura disease (KD), but they have been considered to be two distinct entities based on their histological features. Orbital and adnexal involvement in ALHE is rar...

1. Chacon AH, Mercer J. Successful management of angiolymphoid hyperplasia with eosinophilia in a split‐face trial of topical tacrolimus and timolol solution. G Ital Dermatol Venereol 2014. 2. Lembo S, Balato A, Cirillo T, Balato N. A long‐term follow‐up of angiolymphoid hyperplasia with eosinophilia treated by corticosteroids: When a traditional therapy is still up‐to‐date. Case Rep Dermatol 2...

Background Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare vascular proliferative disorder mainly located in the periauricular region. The etiopathogenesis of ALHE is unknown, and it is still controversial as to whether the entity represents a benign vascular neoplasm or an inflammatory process. Aim Recently, the intracytoplasmic staining pattern of Wilms tumor 1 (WT1) on immunoh...

A healthy 47-year-old white woman presented with 4 vascular-appearing plaques on the left upper part of the forehead (Figure 1A), which had been present for approximately 9 years. On physical examination, there was a 1.031.2-cm pink plaque with 3 similar-appearing papules above it measuring 0.4 to 0.8 cm. One lesion extended into the hairline. Two 3-mm punch biopsy specimens were obtained, whic...

Angiolymphoid hyperplasia with eosinophilia (ALHE), also known as epitheliod hemangioma is an uncommon benign vascular tumor of the skin. It usually presents as nodules and erythema over the ears, forehead, or scalp. Histologically, the lesion is composed of a combination of immature blood vessels, endothelial cells with distinct epitheliod appearance and chronic inflammatory cell infiltration ...

Background: Angiolymphoid hyperplasia with eosinophilia (ALHE) is characterized by irregularly-shaped blood vessels with an inflammatory infiltrate. While absent from normal skin, plasmacytoid dendritic cells (pDCs) infiltrate the skin upon injury and during several infectious, inflammatory, and neoplastic entities. In addition to providing anti-viral resistance, pDCs link the innate and adapti...

Angiolymphoid hyperplasia with eosinophilia (ALHE), also known as epithelioid hemangioma, is a chronic, benign vascular proliferation for which no cases of malignant transformation have been reported to date. Spontaneous resolution has been described in some patients, particularly in those with small lesions. ALHE is characterized by a high rate of recurrence (approximately 30%), regardless of ...

BACKGROUND Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign but potentially disfiguring vascular lesion. It is usually characterized by dermal and subcutaneous nodules, primarily in the head and neck region. Spontaneous regression is common, but persistent or recurrent lesions may require treatment. Several treatments have been reported but surgery is the most efficient one. MET...