An unusual case of a mucin secreting benign microfollicular adenoma of the thyroid in a 30 year old euthyroid woman is reported. Histologically, the lesion was characterised by follicular cells with the appearance of signet ring cells. Histochemistry showed the mucin content of these cells to consist uniformly of sulphated acid mucins; positive thyroglobulin immunostaining was also shown. The p...

This investigation was based on the hypothesis that weakly immunogenic, breast cancer-associated Ags, the products of mutant or dysregulated genes in the malignant cells, will be expressed in a highly immunogenic form by semiallogeneic IL-2-secreting fibroblasts transfected with DNA from breast cancer cells. (Classic studies indicate that transfection of genomic DNA can stably alter both the ge...

BACKGROUNDS/AIMS The diagnosis for cystic neoplasm of pancreas is based on the morphologic criteria through imaging studies, but the pre- and postoperative diagnoses are often inconsistent. This study aims at the analysis of clinical characteristics and the results of surgical treatments. METHODS A retrospective review was performed on 93 patients who have undergone surgery for pancreatic cys...

Calcitonin-secreting neuroendocrine neoplasms of the lung are rare, with few cases reported in literature. Differentiating between medullary thyroid carcinoma and an ectopic source calcitonin secretion can represent a complex diagnostic conundrum for managing physicians, unnecessary thyroidectomy This manuscript reports case hypercalcitonaemia from metastatic neoplasm concurrent pathology summa...

In ageing human adrenal glands there occur some morphological changes which result in alterations of their cortex endocrine function. Glucocorticoid-excreting cells in the zona glomerulosa live longer than androgen-producing cells in the zona reticularis, which undergo significant apoptosis. Therefore, in elderly humans cortisol levels are normal (significantly higher than at young age), while ...

We present the case of a 93-year-old virilized woman with an androgen-secreting ovarian tumor. This rare ovarian sex cord stromal tumor behaved in a malignant fashion. Various aspects of the presentation, diagnosis, and treatment of these tumors are discussed.

Background Esthesioneuroblastoma is an uncommon malignant neoplasm that arises from the olfactory neuroepithelium. In this article we report a case of esthesioneuroblastoma presenting concomitantly with a growth-hormone (GH)-secreting pituitary macroadenoma. Results A 52 year old woman underwent surgery for suspected nasal polyps. Intralesional debulking of an intranasal tumor disclosed a low-g...

Polycystic ovary syndrome (PCOS) is a disorder affecting approximately 5-10% of reproductive aged women [1]. Initially described by Stein and Leventhal in 1935 [2] as a combination of polycystic ovaries, amenorrhoea, hirsutism and obesity, it has been defined in different ways over the years. Finally, in 1990 the National Institutes of Health (NIH) established the new diagnostic criteria for th...