SIR, We previously reported an autoinflammatory disease associated with nucleotide-binding oligomerization domain containing protein 2 (NOD2) gene mutations, designated as NOD2-associated autoinflammatory disease (NAID) [1, 2]. To date, none of the studies of NOD2 mutations have demonstrated spontaneous inflammation in NOD2-associated diseases [3]. Herein we report a patient with NAID to illust...

LINKED CONTENT This article is linked to Khanna & Camilleri papers. To view these articles, visit https://doi.org/10.1111/apt.16143 and https://doi.org/10.1111/apt.16290

LINKED CONTENT This article is linked to Khanna & Camilleri and Tobi et al papers. To view these articles, visit https://doi.org/10.1111/apt.16143 https://doi.org/10.1111/apt.16270

disorders and the potential role of eosinophils. Gastroenterol Clin North Am 2008;37:383–95. 25. Park MI, Camilleri M. Is there a role of food allergy in irritable bowel syndrome and functional dyspepsia? A systematic review. Neurogastroenterol Motil 2006;18:595–607. 26. Zuo XL, Li YQ, Li WJ, et al. Alterations of food antigenspecific serum immunoglobulins G and E antibodies in patients with ir...

Michael Camilleri, Paula Carlson, Alan R. Zinsmeister, Sanna McKinzie, Irene Busciglio, Duane Burton, Essam A. Zaki, and Richard G. Boles Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) and Department of Health Sciences Research, Division of Biostatistics, College of Medicine, Mayo Clinic, Rochester, Minnesota; Division of Medical Genetics and the Saban Researc...

Ogilvie syndrome, or acute colonic pseudo-obstruction, is a severe distension of the colon caused by decreased large bowel motility in the absence of a mechanical obstruction. It can be a consequence of medical treatment such as with clozapine. An 82-year-old male with Alzheimer disease under treatment with antipsychotics (clozapine) was admitted with abdominal distension and constipation. On e...

By 1985, Andrea Rinaldo was losing interest in fluid mechanics. The newly appointed full professor of hydrodynamics at Italy’s University of Trento had excelled in studying the intricacies of eddies, vortices, and fluid flow through porous media. But Rinaldo, lacking excitement, yearned for new avenues of research, seeking, he says, his road to Damascus. As part of his quest, Rinaldo attended a...