In rabbits hyperimmunized with pneumococcal vaccine high concentrations of gamma globulin are produced. In such rabbits, plasma volume was determined with (131)I-labelled rabbit albumin and red cell volume with (51)-Cr-labelled autologous red cells. It was found that the plasma volume increased with increasing gamma globulin concentration, the highest values observed being about 10 gm. per cent...

In a study of the serum proteins in respiratory distress syndrome of the newborn (RDS), Hardie, Heese, and Kench (1965) found that the concentration of electrophoretically separated y-globulin was significantly reduced below the levels normally found in umbilical cord blood, and fell even further in the first few days of life. Later, Hardie and Kench (1967) demonstrated reduced concentrations o...

Gc-globulin has been found in bronchoalveolar lavage fluid in patients with chronic obstructive pulmonary disease (COPD) and adult respiratory distress syndrome (ARDS) and has been shown to enhance neutrophil chemotaxis to C5-derived peptides in vitro. We proposed that Gc-globulin may enhance the inflammatory response in lungs by influencing monocyte chemotaxis to C5-derived peptides as it does...

We determined concentrations of magnesium, total protein, albumin, and globulin in more than 74 000 serum specimens from patients and noted a direct linear relationship between the concentration of magnesium in serum and the concentrations of total protein, albumin, and globulin in serum. Albumin and magnesium concentrations are linearly related at high and low albumin concentrations; within th...

The total concentrations of alpha(2) globulin and two of its components, haptoglobin and caeruloplasmin, have been determined in the sera from 78 patients with primary malignant diseases of lympho-reticular tissue (reticuloses). The total alpha(2) globulin fraction was significantly raised only in Hodgkin's disease. The serum haptoglobin was also significantly increased in Hodgkin's disease and...

The immunohistochemical composition of amyloid deposits in secondary human amyloidosis and experimental amyloidosis in rabbits was studied by means of the "fluorescent antibody" technique of Coons et al. Quantitative studies of the relative amounts of gamma globulin present in the amyloid deposits by the use of radioiodinated fluorescent antibody are reported. It is concluded that amyloid depos...

BACKGROUND Gc-globulin (vitamin D-binding protein) appears to have important functions in addition to its role as a carrier of vitamin D. APPROACH We reviewed recent studies focusing on the pathophysiologic functions and clinical significance of Gc-globulin. RESULTS Serum concentrations of Gc-globulin, as determined by immunoassay techniques, are decreased in severe injury. The extent of th...