In just 10 years from its discovery in 2000, interleukin-23 has quickly moved from being recognized as a pro-inflammatory cytokine to a key player and potential therapeutic target in psoriasis.

The recent advances in the understanding of psoriasis pathogenesis have clarified the pivotal role of interleukin (IL)-23. It is a heterodimeric cytokine consisting of two subunits, the unique p19 and the p40, which are shared with IL-12. The basic role of IL-23 in psoriasis is the activation and maintenance of the T-helper 17 pathway. New research findings indicate that IL-23 is more important...

The Danish sperm donor number 7042 has fathered several offspring with neurofibromatosis type 1 (NF1) worldwide. NF1 is caused by loss-of-function mutations in the NF1 gene and more than 1000 NF1 mutations are identified. Analysis of the donor sperm demonstrated gonosomal mosaicism with an intragenic deletion involving exons 15-29 in the NF1 gene. At the two Danish reference centres for NF1 pat...

introduction: data on imaging findings in pulmonary complications of chemical agents is scarce. the current study aimed to evaluate radiological findings of late onset pulmonary complications in chemical warfare victims (cwv) and to guide pulmonologists in diagnosis of these subjects.   materials and methods: ninety- three male cwv were enrolled in this prospective study, 20-25 years (mean=23) ...

background radiography plays an important role in the detection of interproximal caries. objectives the aim of the present study was to determine diagnostic accuracy of chargecoupled devices (ccd), photo stimulable phosphor (psp) and film radiography in detecting non-cavitated caries. patients and methods seventy-two non-cavitated approximal surfaces of extracted human posterior teeth were radi...

  Introduction: Data on imaging findings in pulmonary complications of chemical agents is scarce. The current study aimed to evaluate radiological findings of late onset pulmonary complications in chemical warfare victims (CWV) and to guide pulmonologists in diagnosis of these subjects.   Materials and Methods: Ninety- three male CWV were enrolled in this prospective study, 20-25 years (mean=23...