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Methods The case records of patients with auto inflammatory syndrome were studied to assess history and site of VTE. Subtype of auto inflammatory disease was noted along with risk factors for VTE and therapy for auto inflammatory disease. In addition it was assessed if auto inflammatory disease had been clinically active at the time of VTE and whether inflammatory markers were elevated in the 6...
The effect of light on the partitioning of resources between photosynthesis and chemical defence was studied in Eucalyptus cladocalyx F. Muell. This species allocates up to 15% of leaf nitrogen to the constitutive cyanogenic glycoside, prunasin, making it an ideal system for studying resource allocation. By controlling the level of leaf nitrogen we were able to test the hypothesis that light li...
Background and purpose: Non selective non-steroidal anti-inflammatory drugs and ciclooxygenase 2 inhibitors provide symptoms relief in osteoarthritis (OA), but produce several adverse effects (AE), which supports the search for other options. D-002, a mixture of higher aliphatic beeswax alcohols, has been shown to produce anti-inflammatory effects experimentally. This double-blind study investi...
Bypassing tyrosine kinases responsible for Stat5a/b phosphorylation would be advantageous for therapy development for Stat5a/b-regulated cancers. Here, we sought to identify small molecule inhibitors of Stat5a/b for lead optimization and therapy development for prostate cancer and Bcr-Abl-driven leukemias. In silico screening of chemical structure databases combined with medicinal chemistry was...
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