A method for monitoring the biological exocytotic phenomena on a microfluidic system was proposed. A microfluidic device coupled with functionalities of fluorescence imaging and amperometric detection has been developed to enable the real-time monitoring of the exocytotic events. Exocytotic release of single SH-SY5Y neuroblastoma cells was studied. By staining the cells located on integrated mi...

■ CONTENTS Nanoelectrodes 473 Extraordinary Properties of Nanoelectrodes 474 Nanoelectrode Fabrication 474 Nanoskiving 475 Lithographically Patterned Nanowire Electrodeposition 475 SWNT-Templated Nanowires and MCEM 476 Voltammetry and Double Layer Effects on Nanoelectrodes 476 Effect of Electrical Double Layer 476 Nanoparticle Electrochemistry 477 Monolayer Protected Clusters 477 Stochastic Nan...

even though the use of enzymes as useful analytical reagents when immobilized onto a transducer such as an electrochemical device has been reported in the literature for nearly two decades, the direct, i.e. unmediated electrochemistry of enzymes is, nevertheless, a rather recent development. efforts will be made to introduce the fundamental basis for protein-surface interactions with emphasis o...

Levedopa was sensitively determined based on electrogenerated chemiluminescence (ECL) mechanism through enhancing the weak ECL of electro-oxidized luminal in presence of levodopa, on a multiwall carbon nanotubes (MWCNTs)-modified electrode. Under optimal conditions, the relative ECL emission/levodopa concentration plot was found to be linear from 1.0×10-9 to 1.7×10-7 M and a detection limit of ...

Electrochemistry in combination with mass spectrometry is emerging as a versatile analytical technique in the imitation of oxidative drug metabolism during the early stages of drug discovery and development. Here, we present electrochemical O-dealkylation of phenacetin to acetaminophen by square-wave potential pulses consisting of consecutive sub-second oxidation and reduction steps. This O-dea...

Interactive multimedia module with pedagogical agent (IMMPA) named EC Lab was developed in order to assist students in the learning of Electrochemistry topic. A non-equivalent pre-test post-test control group design investigation was carried out in order to gauge the effect of EC Lab on students’ understanding in the learning of Electrochemistry. Some 127 Form Four students from two secondary s...

This work reviews different types of substrates used for surface-enhanced Raman scattering (SERS) that have been developed in the last 10 years. The different techniques of self-assembly to immobilize metallic nanoparticles on solid support are covered. An overview of SERS platforms developed using nanolithography methods, including electron-beam (e-beam) lithography and focused ion beam (FIB) ...

The polarographic method invented by J. Heyrovsk over 40 years ago has been associated with many successful achievements in many branches of physical and analytical chemistry, particularly in electrochemistry. Following the construction of the polarograph (with the excellent properties of Kuera's dropping mercury electrode incorporated) by Heyrovsk and Shikata, recording the current—voltage cur...

Raman spectroscopy could supply the molecular vibrational process giving detailed information of structure. At same time, electrochemistry provide kinetic and thermodynamic processes. Integration both technology with general definition using spectroscopic approaches for assaying variations triggered through an electrochemistry-based system within electrochemical cell induces a novel technique, ...