A bead-based sedimentation biodetector is studied theoretically. The biodetector operates with a suspension of settling beads, non-settling reporters, and target analytes – all initially suspended in a buffer solution. The reporters can be either fluorescent molecules or small particles. The functionalized beads interact with the reporters and target analytes while settling under the action of ...

− A model for capillary zone electrophoresis (CZE) is presented to carry out the method development of practical separations involving small charged molecules. The model is based on principles and dynamic equations that contain true physicochemical properties of electrolyte solutions and analytes. The basic variables considered in the model are: injection and detection lengths of analytes, elec...

We demonstrate the use of Raman spectroscopy to measure the concentration of many important constituents (analytes) in serum and whole blood samples at physiological concentration in vitro across a multipatient data set. A near-infrared (830-nm) diode laser generates Raman spectra that contain superpositions of Raman signals from different analytes. Calibrations for glucose, cholesterol, urea, ...

Nanoscale sensors enable the detection of analytes with improved signal-to-noise ratio but suffer from mass transport limitations. Molecular shuttles, assembled from, e.g., antibody-functionalized microtubules and kinesin motor proteins, can selectively capture analytes from solution and deliver the analytes to a sensor patch. This two-stage process can accelerate mass transport to nanoscale bi...

Three antituberculosis medications are investigated in this work consist of rifampicin, isoniazid and pyrazinamide. The ultra violet (UV) spectra of these compounds are overlapped, thus use of suitable chemometric methods are helpful for simultaneous spectrophotometric determination of them. A generalized version of net analyte signal standard addition method (GNASSAM) was used for determinatio...