Systemic lupus erythematosus (SLE) is an autoimmune disease and a chronic systematic disease with unknown etiology influential more than one million individuals each year. The aim of this study is to substantiation the impact of IL4, C3 and C4 in patients with Systemic Lupus Erythematosus. During the period 2/January/2013 to 1/October/2013, fifty patients with Systemic Lupus Erythematosus that ...

adult-onset still’s disease (aosd) is a rare systemic inflammatory disorder of unknown etiology. there is not currently any specific serological markers for aosd , and  diagnosis still relying on the exclusion of other likely diagnoses. yamaguchi’s criteria are used as a diagnostic criterion which contains negative serologic markers for other collagen vascular diseases including systemic lupus ...

BACKGROUND Minocycline has increasingly been associated with different adverse auto-immune reactions including drug-induced lupus. OBJECTIVE To identify the scope of minocycline-induced lupus and to characterise its typical features. METHODS Comprehensive Medline and Embase search of the English and non-English literature for case reports of minocycline-induced lupus. RESULTS We included ...

The objective of this study was to determine the utility of anti-nuclear antibody (ANA) testing in the investigation of cutaneous and other lupus symptoms in female carriers of X-linked chronic granulomatous disease (CGD). We undertook a prospective study of 19 carrier mothers attending our institution, with direct questioning of carriers concerning symptoms and testing for anti-nuclear and ant...

Certain drugs are a frequent source of antinuclear antibody (ANA) induction, and ANA is invariably present in the few patients who progress to the drug induced lupus syndrome. This report concerns the fine specificity of the ANA response to hydralazine, penicillamine, and sulphasalazine therapy. Using highly purified individual histones in fluorimetric assays, antihistone antibodies are always ...

Introduction Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by a variable clinical picture and serological abnormalities. Children and adolescents generally have a more severe disease presentation; develop disease damage more quickly than adults with SLE. Diffuse alveolar hemorrhage (DAH) is a rare life-threatening complication in SLE. In this report a case...

BACKGROUND This retrospective study investigated the clinical utility of a positive antinuclear antibody (ANA) test performed outside of the rheumatology setting. Prior studies have investigated the frequency of ANA positivity within the general population. The purpose of this investigation was to evaluate the clinical utility of a positive ANA test result in a real-world setting by reviewing t...

INTRODUCTION Rosacea is a common inflammatory disorder, characterized by a spectrum of facial manifestations. The clinical similarity to other dermatoses, like lupus erythematosus, might lead to misdiagnosis, particularly in patients with elevated antinuclear antibody titers. AIM To assess the frequency, titer and specificity of antinuclear antibodies in rosacea patients and correlate these f...

SLE is the commonest connective tissue disease encountered in clinical practice. It is a multisystem disorder which can involve the skin, mucous membranes, joints, lungs, kidneys, central and/or peripheral nervous system, heart, and the gastrointestinal system. Constitutional features of fever, fatigue, anorexia and weight loss are common. Lupus should be suspected in the following clinical set...