Amyloid beta (Aβ) is a peptide derived from processing of the membrane bound amyloid precursor protein and is a main constituent in amyloid plaques in Alzheimer's disease (AD). The excess Aβ in AD brain may be caused by altered Aβ metabolism, including reduced enzymatic degradation. Our previous enzymatic study of Aβ degradation revealed that intracellular enzymes produced several truncated Aβ ...

The presence of amyloid aggregates of the 42 amino acid peptide of amyloid beta (Aβ42) in the brain is the characteristic feature of Alzheimer's disease (AD). Amyloid beta (Aβ deposition is also found in muscle fibers of individuals affected by inclusion body myositis (sIBM), a rare muscular degenerative disease affecting people over 50. Both conditions are presently lacking an effective therap...

One hallmark of Alzheimer´s disease are senile plaques consisting of amyloid beta (Aβ), which derives from the processing of the amyloid precursor protein (APP). Mitochondrial dysfunction has been linked to the pathogenesis of Alzheimer´s disease and both Aβ and APP have been reported to affect mitochondrial function in isolated systems. However, in intact cells, considering a physiological loc...

Amyloid beta (Aβ), the hallmark of Alzheimer's Disease (AD), now appears to be deleterious in its low number aggregate form as opposed to the macroscopic Aβ fibers historically seen postmortem. While Alzheimer targets, such as the tau protein, amyloid precursor protein (APP) processing, and immune system activation continue to be investigated, the recent discovery that amyloid beta aggregates a...

Objective(s): Neuroprotective effect of creatine (Cr) against β-amyloid (Aβ) is reported in an in vitro study. This study investigated the effect of Cr supplementation on β-amyloid toxicity in vivo. Materials and Methods: Thirty two, male Wistar rats were divided into 4 groups. During ten weeks of study, control group went through no surgical or dietary intervention. At the 4th week of study S...

objective(s): neuroprotective effect of creatine (cr) against β-amyloid (aβ) is reported in an in vitro study. this study investigated the effect of cr supplementation on β-amyloid toxicity in vivo. materials and methods: thirty two, male wistar rats were divided into 4 groups. during ten weeks of study, control group went through no surgical or dietary intervention. at the 4th week of study sh...

Background Among the various risk factors for Alzheimer disease (AD), apolipoprotein E (APOE) genotype ε4 is known to be a strong factor. On other hand, ε2 have protective effect. It not yet clear how amyloid positivity according APOE differs by diagnostic criteria. Also, there were no studies showing ethnic difference in effects of on amyloid-beta (Aβ) between American and Asian. The aim this ...

Background: There is consistent evidence of the potential benefits lithium attenuating mechanisms neurodegeneration, including those related to pathophysiology Alzheimer’s disease (AD), and facilitating neurotrophic protective responses, maintenance telomere length. The aim was investigate effect pre-treatment with on amyloid-beta (Aβ)-induced toxicity length in neurons. Methods: Cortical neuro...

Amyloid protein aggregates are associated with dozens of devastating diseases including Alzheimer's, Parkinson's, ALS, and diabetes type 2. While structure-based discovery of compounds has been effective in combating numerous infectious and metabolic diseases, ignorance of amyloid structure has hindered similar approaches to amyloid disease. Here we show that knowledge of the atomic structure o...