Objective(s) Single injection of naloxone, a selective antagonist of morphine, prior to the drug conditioning testing was used to investigate on morphine dependence. Materials and Methods Conditioning to morphine (2.5-10 mg/kg, s.c.) was established in adult male Wistar rats (weighing 200-250 g) using an unbiased procedure. Nitric oxide agents were microinjected into the central amygdala pri...

Introduction: There are many similarities between memory impairment in patients suffering from Alzheimer and animals treated by Cannabinoids. The agonists of Cannabinoid receptors affect on a variety of memories and leanings. The present study aims to investigate the role of α-1-adrenergic receptors in central region of amygdala in state-dependent learning induced by WIN55,212-2 (cannabin...

Effects of intra-central amygdala administration of L-arginine, a nitric oxide precursor, and NG-nitro-L-arginine methyl-ester (L NAME), a nitric oxide synthase inhibitor, on the morphine-induced sensitization and also on the expression of morphine-induced place conditioning in rats were studied. Subcutaneous (s.c.) administration of morphine (2.5, 5 and 7.5 mg/kg) induced place conditioning. R...

posttraumatic stress disorder (ptsd) is a disorder of emotional and mental stress occurring as an outcome of injury or severe emotional shock. several neuroimaging studies in humans have shown the functions and relationship between the anatomical changes of brain and ptsd. the three major areas of the brain are affected by ptsd .these three areas are the amygdala, hippocampus and prefrontal cor...

introduction: many studies have shown that amygdala kindling produces synaptic potentiation by induction of changes in the neuronal electrophysiological properties and inward currents both in epileptic focus and in the areas which are in connection with the epileptic focus and have important role in seizure development and progression such as hippocampal ca1 region. however, cellular mechanisms...

Introduction: Aggressive behavior is a major issue in the field of mental health. Pharmacotherapy is often used for the treatment of violent individuals. A neurochemical system most consistently linked with aggression is the GABAergic system. The aim of the present investigation was to examine the effect of muscimol (GABAA agonist) 250 and 500 ng/rat and picrotoxin (GABAA antagonist) 1.5 and...

Preclinical models of Alzheimer's disease (AD) suggest that volumetric reductions in medial temporal lobe (MTL) structures manifest before clinical onset. AD polygenic risk scores (PRSs) are further linked to reduced MTL volumes (the hippocampus/amygdala); however, the relationship between PRS and specific subregions remains unclear. We determine AD-PRSs a large sample young participants (N = 7...

the most important risk factors for anxiety disorders include genes, early life stress, and current stress. these factors do not act independently but interact with each other throughout human development through examples such as epigenetic modifications and complex forms of learning. the neural substrate of pathological anxiety includes hyperactivity in the amygdala and other limbic brain regi...

introduction: previous studies have shown that the basolateral amygdale (bla) is rich of cb1 cannabinoid receptors and involved in cannabinoid-induced antinociception. also, it seems that there are functional interactions between the cannabinoid cb1 and opioid receptors in the process of sensitization to opiates. in the present study, we tried to examine the role of intra-bla cannabinoid recept...

Abstract Teleost fish exhibit extraordinary cognitive skills that are comparable to those of mammals and birds. Kin recognition based on olfactory visual imprinting requires neuronal circuits were assumed be necessarily dependent the interaction mammalian amygdala, hippocampus, isocortex, latter being a structure teleost lacking. We show teleosts—beyond having hippocampus pallial amygdala homol...