ABSTRACT. The present study describes synthesis of some new luminol derivatives, which might play an important role in biological active agents. These synthesized compounds are functionalized based on (LM) with different carboxylic drugs such as mefenamic acid, ibuprofen, diclofenac sodium, and ampicillin). Synthesis processes was conducted by converting group the investigated into acid chlorid...

We examined the effect of three clinically used antimicrobials on Streptococcus mutans UA159 biofilm detachment under flow conditions. Sodium fluoride (NaF) and chlorhexidine at MIC levels promoted biofilm detachment and inhibited detachment when concentrations were higher than the MIC and reduced detached-cell viability only at high concentrations. Ampicillin at all concentrations tested inhib...

Antibiotics as additives in animal feedstuffs are forbidden in many countries in the world, but they are still abused. A micellar electrokinetic capillary chromatography method was performed at 25 C and 30 kV (under pressure 15 mbar) using 25 mmol dm phosphate buffer (pH = 8.0) containing 70 mmol dm sodium dodecysulfate (SDS) and 10 % (volume fraction) methanol as the background electrolyte fo...

Bactericidal efficacy of gold nanoparticles conjugated with ampicillin, streptomycin and kanamycin were evaluated. Gold nanoparticles (Gnps) were conjugated with the antibiotics during the synthesis of nanoparticles utilizing the combined reducing property of antibiotics and sodium borohydride. The conjugation of nanoparticles was confirmed by dynamic light scattering (DLS) and electron microsc...

A newly described 6beta-amidinopenicillanic acid derivative, mecillinam (formerly called FL 1060), showed a high in vitro activity against Enterobacteriaceae. The effect on Escherichia coli was bactericidal and was due to lysis of the cells. The longer the culture grew under the influence of mecillinam or the lower the inoculum, the greater the bactericidal effect. The morphology of the cells c...

Chromobacterium violaceum is a gram negative straight rod, 0.8-1.2 by 2.5 to 6.0 m, which is motile by one polar flagella and one to four lateral flagella. The organism inhabits soil and water and is often found in semitropical and tropical climates. Infections in humans are rare. We report a case of infection caused by strains of C. violaceum. A 38-year-old male patient was admitted to KyungHe...

In human physical conditions, the interaction of topiramate amyl cephalosporin cefotaxime (TACC) with bovine serum albumin (BSA) and the effects of coexistent drugs and metal ions were investigated by fluorescence spectroscopy. Results showed that the effect between TACC and BSA was static fluorescence quenching process, and the electrostatic attraction plays an important role in the conjugatio...