Self-assembly of linear amphiphiles is a well-known phenomenon, and the number of different structures observed both in the solid-state and in selective solvents is exceedingly large. It is difficult to envision a diblock amphiphile that would not undergo self-assembly, and in this context, the terms “linear amphiphilic” and “self-assembling” are nearly synonymous. Branched amphiphiles such as ...

Homologous dicarboxyl dendritic amphiphiles-RCONHC(CH(3))(CH(2)CH(2)COOH)(2), 4(n); and ROCONHC(CH(3))(CH(2)CH(2)COOH)(2), 5(n), where R=n-C(n)H(2)(n)(+1) and n=13-22 carbon atoms-were synthesized. Critical micelle concentrations (CMCs) in aqueous triethanolamine solutions and at pH 7.4 were measured along with hemolytic activity (effective concentrations, EC(10)) in phosphate-buffered saline (...

We report here that the release mechanism of free camptothecin from self-assembling drug amphiphiles can be regulated by use of different linker groups. Our results highlight the significance of the linker group of drug amphiphiles on the drug release efficiency and their consequent in vitro efficacy.

ABA-type amphiphiles bearing a triazole-based aromatic block were easily synthesized using click chemistry, which act as fluorescent turn-off Hg(2+)-chemoprobes in an aqueous solution. Interestingly, the metal-binding process of amphiphiles induced nanoassemblies even below the CMCs, and the binding stoichiometry affected the morphologies of the resultant nanostructures.

With the development of deoxyribonucleic acid (DNA) nanotechnology, various DNA nanostructures and devices have been constructed, which exhibit potential applications in material science biomedicine. Taking advantage programmability biocompatibility DNA, novel building block to chemically functionalize with hydrophobic organic molecules has attracted more attention. Driving by amphiphilicity, D...

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We present an improved version of an earlier Larson-type model of amphiphiles. Detailed descriptions of the algorithms are given and some situations where care must be taken are pointed out We use the model to calculate the condensation transition temperature of amphiphiles in a ternary mixture. The concentration percolation threshold and percolation critical exponent of arnphiphile clusters at...

Model calculations of Langmuir monolayers: Pressure effects on tilting behavior of idealized amphiphiles" (1996). Model amphiphiles consisting of lines of Lennard-Jones ͑LJ͒ centers are investigated to determine the effect of pressure and molecular geometry on ground-state tilting behavior. Both the amphiphile length and the intramolecular distance between LJ centers is varied. The results give g...

We report synthetic six-tailed mimics of the bacterial glycolipid Lipid A that trigger changes in the internal ordering of water-dispersed liquid crystal (LC) microdroplets at ultralow (picogram-per-milliliter) concentrations. These molecules represent the first class of synthetic amphiphiles to mimic the ability of Lipid A and bacterial endotoxins to trigger optical responses in LC droplets at...