Differentiation Syndrome (DS) has been identified in a subset of patients undergoing treatment with novel classes differentiating therapies for acute myeloid leukemia (AML) such as IDH and FLT3 inhibitors. While DS is well-known treatment-related complication promyelocytic (APL), efforts are still ongoing to standardize diagnostic parameters AML. Though the rates incidence vary, many signs symp...

granulocytic sarcomas (chloromas) are rare extramedullary tumors consisting of primitive granulocytic cells. we report here on a case of a 23-year-old man who presented with a generalized swelling. he is known case of acute myelomonocytic leukemia. granulocytic sarcomas are rare, destructive, extramedullary tumor masses that consist of immature granulocytic cells. in this unusual patient's case...

Background: Acute myeloid leukemia (AML) is one of myeloid malignancies which the risk increases with age increment. It is categorized based on genetic aberrations. Some of these genetic disorders can determine minimal residual diseases (MRD) and prognosis of AML patients. Wilms tumor (WT1) over expression is found in AML patients. The aim of this study was to determine the frequency of WT1 ove...

ABSTRACT Three patients were diagnosed at our facility with therapy-related acute myeloid leukemia (t-AML) but had differing etiologies. Patient A was a 30-year-old male history of lymphoblastic in remission. The patient admitted to the hospital early 2019 for pain control and concurrent pancytopenia. bone marrow biopsy performed because concern relapsed disease. showed 96.6% blasts 95...

Acute myeloid leukemia (AML-M7) is a type of pediatric AML accounting for 3–10% of primary childhood AML and children may present with a broad variety of symptoms including low-grade fever, diarrhea, easy bruising, failure to gain weight and life-threatening conditions. We report a rare case of AML .A 26-month-old boy who presented with weakness and fatigue. He was diagnosed as a case of AMLM-7...

Evaluation of ATG7 and LC3 Autophagy Genes Expression in Newly Diagnosed AML patients Background and aim: Autophagy, known as cell death type II, is a housekeeping pathway that currently has been worked on in matters of tumorigenesis and leukemogenesis. Therefore, in this study expression levels of ATG7 and LC3 as two key genes are targeted in AML patients. Material and method: This...

Background: Benzene has been classified as group 1 human carcinogens in the environment by the International Agency for Research on Cancer (IARC) mainly because of its ability to cause acute myeloid leukemia (AML). This study was conducted to detect any probable association between urban benzene pollution concentration and occurrence of AML in different regions of Tehran.  Methods: In thi...

Background:Brain and Acute Leukemia Cytoplasmic (BAALC) is a gene which its expression is confined to progenitor cells; therefore, no expression has been illustrated in mature cells of bone marrow or white blood cells (WBC).  In addition, high BAALC expression is associated with poor prognosis in Acute Myeloid Leukemia (AML) individuals and is considered as an important risk factor in Cyto...

Abstract Acute myeloid leukemia (AML) remains an incurable malignancy despite recent advances in treatment. Recently a number of new therapies have emerged for the treatment AML which target BCL-2 or membrane receptor CD38. Here, we show that with Venetoclax and Daratumumab combination resulted slower tumor progression reduced growth both vitro vivo. These data provide evidence clinical evaluat...

background: the glutathione s-transferase (gst) family of metabolising enzymes plays an important role in the detoxification of mutagens and carcinogens. the expression of many of these cancer susceptibility enzymes is genetically polymorphic. an increased frequency of gst-null genotypes has been associated with several malignancies. objective: to investigate the rate of gstt1 and gstm1 null ge...