نتایج جستجو برای: alps
تعداد نتایج: 5744 فیلتر نتایج به سال:
The Mesoscale Alpine Programme (MAP) was conducted over the European Alps in September-November 1999. During autumn, heavy rains and floods can occur when baroclinic troughs move over the region, and moist air flows from the Mediterranean Sea toward the southern Alps. Dual-polarimetric Doppler and vertically pointing radar data collected during MAP on the Mediterranean side of the Alps provided...
Definite Agent Logic Programs (definite ALPs), recently introduced by Drescher, Schiffel and Thielscher, provide an interesting alternative to imperative languages like GOLOG for specifying agent behavior. The main advantages of ALPs is that they are fully declarative and independent of the underlying action theory. In this paper we extend the expressiveness of ALPs by introducing nonmonotonic ...
Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of abnormal lymphocyte survival caused by defective Fas-mediated apoptosis, leading to lymphadenopathy, hepatosplenomegaly, and an increased number of double-negative T cells (DNTs). Treatment options for patients with ALPS are limited. Rapamycin has been shown to induce apoptosis in normal and malignant lymphocytes. Since ALPS is cau...
Autoimmune lymphoproliferative syndrome (ALPS) is caused by genetic defects decreasing Fas function and is characterized by lymphadenopathy/splenomegaly and expansion of CD4/CD8 double-negative T cells. This latter expansion is absent in the ALPS variant named Dianzani Autoimmune/lymphoproliferative Disease (DALD). In addition to the causative mutations, the genetic background influences ALPS a...
Autoimmune lymphoproliferative syndrome (ALPS) is characterized by childhood onset of lymphadenopathy, hepatosplenomegaly, autoimmune cytopenias, elevated numbers of double-negative T (DNT) cells, and increased risk of lymphoma. Most cases of ALPS are associated with germline mutations of the FAS gene (type Ia), whereas some cases have been noted to have a somatic mutation of FAS primarily in t...
Autoimmune lymphoproliferative syndrome (ALPS) is a prototypic disorder of abnormal lymphocyte homeostasis. In the September 2005 issue of The Iranian Journal of Allergy, Asthma and Immunology, a patient with clinical features consistent with ALPS was described. Although the clinical presentation was in favor of ALPS, a precise diagnosis needed more laboratory evaluations.
Alkyl-lysophospholipids (ALPs) represent a new class of antitumor drugs that induce apoptotic cell death in a variety of tumor cell lines. Although their precise mechanism of action is unknown, ALPs primarily act on the cell membrane, where they inhibit signaling through the mitogen-activated protein kinase (MAPK) pathway. Because stimulation of the stress-activated protein kinase/c-Jun NH2-ter...
The Age-Layered Population Structure (ALPS) paradigm is a novel metaheuristic for overcoming premature convergence by running multiple instances of a search algorithm simultaneously. When the ALPS paradigm was first introduced it was combined with a generational Evolutionary Algorithm (EA) and the ALPS-EA was shown to work significantly better than a basic EA. Here we describe a version of ALPS...
Heterozygous mutations in the CD95 (APO-1/Fas) receptor occur in most individuals with autoimmune lymphoproliferative syndrome (ALPS) and dominantly interfere with apoptosis by an unknown mechanism. We show that local or global alterations in the structure of the cytoplasmic death domain from nine independent ALPS CD95 death-domain mutations result in a failure to bind the FADD/MORT1 signaling ...
The taxonomy of Sattleria Povolný from the high mountain systems on the Balkan Peninsula and the adjacent parts of the Alps (south-eastern Alps, Dinaric Alps, Rila Mountains) is revised based on recently collected material and re-examined museum vouchers. Adult morphology and molecular data of the COI barcode region support the existence of six strictly allopatric species in this area, includin...
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