نتایج جستجو برای: alphasynuclein
تعداد نتایج: 24 فیلتر نتایج به سال:
Introduction In 1997, based on linkage analyses of Italian and Greek families, alpha-synuclein was identified first as a gene involved in the pathogenesis of autosomal-dominantly inherited, early-onset Parkinson’s disease (PD). A nucleotide transition at position 209 from guanosine to adenosine (G209A), resulting in an alanine to threonine substitution at position 53 (A53T) on the amino acid le...
Although soluble oligomers are regarded as the most toxic aggregates of Abeta, the amyloidogenic nature of Abeta certainly is not accidental and should play a role in the still unknown physiological functions of Abeta. The testable hypothesis put forward here postulates that short Abeta oligomers can crosslink the neurotrophin receptor p75 with APP and other proteins and mediate a direct cooper...
Recently Alzheimer’s Disease Neuroimaging Initiative (ADNI) observation has reported that MCI who has higher level of amyloid decline his cognitive ability faster than MCI who has a relative lower amyloid in his brain. However, in a normal patient’s brain in which the amyloid level was almost equal to that of an MCI patient’s brain, the cognitive ability was not at all declined. Consequently, a...
Cells respond to stimuli by changes in various processes, including signaling pathways and gene expression. Efforts to identify components of these responses increasingly depend on mRNA profiling and genetic library screens, yet the functional roles of the genes identified by these assays often remain enigmatic. By comparing the results of these two assays across various cellular responses, we ...
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