Whether alloxan or diabetes is responsible for the lowered concentration of amino acids in aqueous humor and lenses of rabbits made diabetic by this drug was investigated. The rate of accumulation of <C-cycloleucine (l-amino cyclopentane carboxylic acid) in both posterior aqueous and lens was depressed to essentially the same degree in rabbits made diabetic by pancreatectomy or by alloxan. The ...

We have measured lipid peroxidation and the activity of antioxidant enzymes in lenses of alloxan injected rats. After 12 weeks alloxan treated rats developed lens cataract. Diabetes rats had both lower lens weight and lower level of proteins in soluble fraction of lens homogenate. Alloxan treatment is associated with a significant increase of thiobarbituric acid reactive substances and the acti...

Experiments were performed to compare the effects of cholesterol feeding in (a) control rabbits, (b) alloxan-diabetic rabbits, and (c) rabbits injected with alloxan while the pancreas was temporarily occluded from the circulation. The alloxan-diabetic rabbits consumed significantly higher quantities of cholesterol and food and had serum cholesterol and lipoprotein (S(f) 5-9 and S(f) 16-30) conc...

Based on the hypothesis that consistent hyperglycemia can result in insulin resistance, we explored the induction of non-insulin dependent diabetes mellitus (NIDDM) using diet of high glycemic/low fat index and compared the effects on the physiology and histology of the rats. The rats were divided into 3 groups. DM was induced in the first group by single intraperitoneal injection of 150mg/kg a...

1. Concentrations of ketone bodies, free fatty acids and chloride in fed, 24-120h-starved and alloxan-diabetic rats were determined in plasma and striated muscle. Plasma glucose concentrations were also measured in these groups of animals. 2. Intracellular metabolite concentrations were calculated by using chloride as an endogenous marker of extracellular space. 3. The mean intracellular ketone...

Effect of continuous administration of dried 75% methanolic extract of fruits of Terminalia belerica (Combretaceae) suspended in water was studied in alloxan induced hyperglycemia and antioxidant defense mechanism in rats. T. belerica prevented alloxan-induced hyperglycaemia significantly from 6th day of administration and there was 54% reduction on 12th day. Oxidative stress produced by alloxa...

The chemical properties of these two substances are strikingly similar. Both compounds are irreversibly decomposed under biological conditions. Alloxan has a half life of 1 minute (1) and dehydroascorbic acid has a half life of a few minutes (2). Alloxan is readily reduced to dialuric acid (3) with which it forms alloxantin (3). Dehydroascorbic acid is readily reduced to ascorbic acid (4) and a...

Diabetes mellitus (DM) is a metabolic disorder in which the carbohydrate and lipid metabolism is improperly regulated by insulin. Many indigenous Indian medicinal plants have been found to be successfully used to cure diabetes. Herbal drugs are considered to be less toxic and free from side effects than synthetic ones. Keeping this view, the study aimed to evaluate the antidiabetic and hypoglyc...

Short term effects of insulin on total brain and branchial Na+K+ ATPase, Ca2+ ATPase and Na+, K+ and Ca2+ ions were investigated in A. testudineus. The increase in brain Ca2+ ATPase after alloxan treatment may account for an increased amount of intracellular calcium required for biochemical events taking place inside the cells. Branchial Na+K+ATPase was significantly stimulated while Ca2+ ATPas...

Abstract Background Various bleaching agents are used in food industries among which some reacts to form alloxan. Therefore, the alloxan can indirectly enter a human body and thus an important aspects for studying its effect on development. In present study, of was studied climbing ability, pupation emergence flies. Fifty first instar larvae were introduced separately vials containing 0.001, 0....