Rhodanese is the major detoxifying enzyme for cyanide and requires sulphur for its action. Allium cepa (Onion) is rich in organosulphur which may serve as an antidote for cyanide poisoning by supplying sulphur to the enzyme rhodanese. The possible effects of Allium cepa on rhodanese activity during cyanide toxicity was investigated in male Wistar rats. Sixty Wistar rats (150-180 g) were divided...

AIM To investigate the antioxidant potential of two Allium cepa L. extracts. MATERIAL AND METHODS The antioxidant activity of the two extracts (encoded EC1 and EC2) was assessed using two methods: DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging capacity and determination of their reducing power; phytobiological, studies were performed using grains of Triticum aestivum L., Falmura variety. R...

The term 'shallot' in Croatia denotes three genetically and morphologically different, vegetatively reproduced relatives of the common onion, Allium cepa L., which are mainly traditionally cultivated for consumption and as a spice: A. cepa Aggregatum group, (2n = 2x = 16), A. × proliferum (Moench) Schrad. (2n = 2x = 16) and A. × cornutum Clementi ex Vis. (2n = 3x = 24). This paper reviews the r...

N-nitroso compounds, such as N-nitrosodiethylamine (NDEA), can be formed by the reaction of secondary amines with nitrosating agents, and are suspected to be involved in tumors in humans. NDEA has been considered a weak carcinogen in genotoxic assays probably due to the inefficient nitrosamine activation system that is used and/or to the efficient repair system. In this work, we evaluated the s...

The objective of the present study was to evaluate the anxiolytic and anticonvulsant activity of the methanolic extract of Allium Cepa Linn (MEAC). After preliminary phytochemical evaluation, acute oral toxicity test, anxiolytic activity of methanolic extract of Allium Cepa bulbs at doses of 200 and 400 mg/kg was assessed using elevated-plus-maze (EPM), open field test (OFT), light & dark trans...

INTRODUCTION Alprazolam is a triazolobenzodiazepine used in panic disorders and other anxiety states. Target organ of Alprazolam is CNS, causing depression of respiration and consciousness. AIM This study aimed to estimate the genotoxic potential of Alprazolam using Allium cepa test. METHODS Allium cepa is one of the most suitable plants for detecting different types of xenobiotics. The tes...

Allium cepa L. is known to possess numerous pharmacological properties. Our aim was to examine the in vitro effects of Allium cepa L. extract (AcE) on Porphyromonas gingivalis LPS and Escherichia coli LPS-stimulated osteoclast precursor cells to determine cell viability to other future cell-based assays. Osteoclast precursor cells (RAW 264.7) were stimulated by Pg LPS (1 μg/mL) and E. coli LPS ...

Eight commonly used spices Syzygium aromaticum, Cinnamonum zeylanicum, Zingiber officinale, Murraya koenigii, Piper nigrum, Trachyspermum ammi, Allium sativum and Allium cepa were tested for in vitro antifungal activity on Aspergillus niger, a causative agent of different destructive disease. Out of eight plant materials used, five showed significant antifungal activity against the test pathoge...

conclusions this study showed that aqueous allium cepa and ixora brachiata root extracts as natural products could be used as alternative drugs in treatment of leishmaniasis. results among tested plant extracts, ixora brachiata root extracts revealed the best activity against leishmania major promastigotes with ic100 value of 2.5 mg/ml and ic50 value of 0.078 mg/ml. patients and methods the par...