Self-incompatibility is considered to be a growth limiting factor in fruit plants. In species with hermaphrodite flowers, S-locus (S-allele) has been accepted control self-incompatibility, and the genetic of this locus provided by multiple genes (alleles). Pear (Pyrus communis L.) belongs Pomoideae from Rosaceae family found have great potential terms ecological features Turkey. To protect thes...

OBJECTIVES There is increasing evidence that rare variants play a role in some complex traits, but their analysis is not straightforward. Locus-based tests become necessary due to low power in rare variant single-point association analyses. In addition, variant quality scores are available for sequencing data, but are rarely taken into account. Here, we propose two locus-based methods that inco...

Asthma is a complex disease, often with evident genetic predisposition; for example, the single‑nucleotide polymorphism (SNP) rs7130588 was significantly associated asthma by genome‑wide association study (GWAS). Analysis of 1000 Genomes Project data suggests that there another SNP, rs6592645, in complete linkage disequilibrium and should present same signal GWAS. However, causal SNP mechanism ...

Sporophytic self-incompatibility (SSI) is a self-pollen recognition system that enforces outcrossing in plants. Recognition in SSI systems is typically controlled by a complex locus (S-locus) with separate genes that determine pollen and stigma specificity. Experimental studies show that S-alleles can be dominant, recessive, or codominant, and that the dominance level of a given S-allele can de...

BACKGROUND Since the dawn of genetics, additive and dominant gene action in diploids have been defined by comparison of heterozygote and homozygote phenotypes. However, these definitions provide little insight into the underlying intralocus allelic functional dependency and thus cannot serve directly as a mediator between genetics theory and regulatory biology, a link that is sorely needed. M...

Detecting gene-gene interaction in complex diseases is a major challenge for common disease genetics. Most interaction detection approaches use disease-marker associations and such methods have low power and unknown reliability in real data. We developed and tested a powerful linkage-analysis-based gene-gene interaction detection strategy based on conditioning the family data on a known disease...

The aim of the present study was to evaluate genotypic distribution calpastatin (CAST) and insulin-like growth factor 1 (IGF1) gene polymorphisms in Tsigai sheep breed. Genomic DNA isolated from blood samples by phenol-chloroform method. A total 56 were genotyped PCR-RFLP Allele genotype frequencies calculated standard procedures. To population-genetic properties, Hardy–Weinberg Equilibrium (HW...