Glucagon-like-peptide-1 (GLP-1) is a gut- and neuro-peptide with an important role in the regulation of food intake and glucose metabolism. Interestingly, GLP-1 receptors (GLP-1R) are expressed in key mesolimbic reward areas (including the ventral tegmental area, VTA), innervated by hindbrain GLP-1 neurons. Recently GLP-1 has emerged as a potential regulator of food reward behavior, an effect d...

Background Hepatitis B virus (HBV) infection is common in Arctic populations and high alcohol intake has been associated with an increased risk of a number of diseases. Yet, a description of the influence of alcohol intake in persons with HBV infection on liver biochemistry is lacking. Objective We aimed to describe the association between reported alcohol intake and liver biochemistry taking i...

BACKGROUND Blood levels of gamma-glutamyl transferase (GGT) are used as a marker for (heavy) alcohol use. The role of GGT in the anti-oxidant defense mechanism that is part of normal metabolism supposes a causal effect of alcohol intake on GGT. However, there is variability in the response of GGT to alcohol use, which may result from genetic differences between individuals. This study aimed to ...

Alcohol forms a significant component of many diets and it supplements rather than displaces daily energy intake. Surprisingly, alcohol intake does not systematically increase body weight. The present study assessed whether a higher level of habitual physical activity in the daily environment is associated with a higher alcohol intake. Alcohol intake as part of total food intake was measured wi...

Adolescents naturally go to bed and awaken late, but are forced to awaken early for school and work. This leads to "social jetlag", a state of circadian desynchrony (CD), in which internal biological rhythms are out of sync with behavioral rhythms. CD is associated with increased alcohol intake in adults, but has been less well-studied in adolescents. The goal of this study was to model adolesc...

Under-reporting of alcohol intake has been frequently reported. However, due to the lack of an objective reference method, e.g. a biomarker, information about the extent of under-reporting of alcohol intake obtained with dietary assessment instruments is not available. The objective of this study was to compare reported alcohol intake data derived from a 24 h recall with a biomarker of recent a...

Momeni, S. 2015. Individual differences in behavior, neurochemistry and pharmacology associated with voluntary alcohol intake. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 205. 76 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9378-3. Alcohol use disorder is a worldwide public health problem and is a disorder with substantial individual var...

This research aimed to provide the first assessment of the contribution of alcohol to Australian adults' diets over time and determine if people reporting alcohol had higher total dietary energy intakes. Secondary analyses of cross-sectional national nutrition surveys from 1983, 1995, and 2011/12 for adults 18 years (n = 26,675) and over were conducted. Alcoholic beverage intake and diet were a...

OBJECTIVES To examine the association between alcohol intake and problem drinking history and bone mineral density (BMD), falls and fracture risk. DESIGN Cross-sectional and prospective cohort study. SETTING Six U.S. clinical centers. PARTICIPANTS Five thousand nine hundred seventy-four men aged 65 and older. MEASUREMENTS Alcohol intake and problem drinking histories were ascertained at...