The experiment was conducted to study the effect of different dietary supplementation alanyl-glutamine dipeptide (AGD) and/or vitamin E (VE) on growth performance, antioxidant indexes, and expression glutathione peroxidase (GPx) peroxisome proliferator-activated receptor α (PPARⱭ) genes in juvenile marine medaka (Oryzias melastigma) seawater acidification. Seven groups triplicate were studied a...

To explore the clinical value of damage control resuscitation combined with alanyl glutamine in treatment severe multiple trauma sufferers is main objective study. A total 120 injury severity score≥16 points who were admitted to our hospital from November 2019 February 2022 selected and separated into blank group intervention (group J M) according random grouping method 40 people each group. Th...

BACKGROUND Low plasma glutamine concentration is an independent prognostic factor for an unfavourable outcome in the intensive care unit (ICU). Intravenous (i.v.) supplementation with glutamine is reported to improve outcome. In a multi-centric, double-blinded, controlled, randomised, pragmatic clinical trial of i.v. glutamine supplementation for ICU patients, we investigated outcomes regarding...

Abstract Background and Aims About 11% of patients requiring dialysis worldwide are treated with peritoneal (PD). With each PD exchange high amounts protein removed from the cavity stemming systemic circulation (reflecting toxin removal, loss serum proteins, inflammatory processes) local processes. Thereby, clinically measured (PPL) is result transperitoneal loss, lymphatic drainage, transmesot...

randomised, double blind controlled trial. Nutrition 1999;15:860 6. Semba RD, Tang AM. Micronutrients and the pathogenesis of human immunodeficiency virus infection. Br J Nutr 1999;81:181 7. Stehle P, Zander J, Mertes N, et al. Effect of parenteral glutamine dipeptide supplements on muscle glutamine loss and nitrogen balance after major surgery. Lancet 1989;i:231 8. O’Riordain M, Fearon KC, Ros...

Mechteld A.R. Vermeulen This thesis approaches amino acid metabolism in critically ill patients from bench to bedside, in which there is a central role for glutamine, citrulline, arginine and enteral nutrition. The relationship between glutamine, citrulline and arginine has been known for decades. Glutamine is converted into citrulline in the gut after which citrulline is converted into arginin...

The ATP-dependent carboxylate-amine/thiol ligase superfamily is known to contain enzymes catalyzing the formation of various types of peptide, such as d-alanyl-d-alanine, polyglutamate, and gamma-peptide, but, curiously, no enzyme synthesizing alpha-dipeptides of l-amino acids is known. We attempted to find such an enzyme. By in silico screening based on the consensus sequence of the superfamil...

AIMS We hypothesized that oral l-glutamine supplementations could attenuate muscle damage and oxidative stress, mediated by glutathione (GSH) in high-intensity aerobic exercise by increasing the 70-kDa heat shock proteins (HSP70) and heat shock factor 1 (HSF1). MAIN METHODS Adult male Wistar rats were 8-week trained (60-min/day, 5 days/week) on a treadmill. During the last 21 days, the animal...

Postcardiac arrest acidosis can decrease survival. Effective medications without adverse side effects are still not well characterized. We aimed to analyze whether early administration of glutamine could improve survival and protect cardiomyocytes from postcardiac arrest acidosis using animal and cell models. Forty Wistar rats with postcardiac arrest acidosis (blood pH < 7.2) were included. The...