Objective(s): To investigate the association of single nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptors gamma (PPARG) with essential hypertension (EH) and additional role of gene– high-density lipoprotein cholesterol (HDL) interaction. Materials and Methods:A total of 1640 patients with EH (806 males, 834 females), with a mean age of 52.5±12.6 years, were selec...

introduction during the process photodynamic therapy (pdt), bleaching of photosensitizer induced by irradiation and generation of reactive oxygen species (ros) can provide some information concerning the efficiency of treatment. since gold nanoparticles (gnps) have been highlighted as efficient drug delivery systems, in this study, by utilizing gnps conjugated with 5 aminolevulinic acid (5-ala-...

The glycopeptide vancomycin has an antimicrobial effect by halting the synthesis of bacterial cell-wall binding D-Ala-D-Ala peptide motif precursor Lipid II. This interaction been extensively investigated using techniques such as XRD and NMR. Here, complexed with Ala-γGlu-Lys-D-Ala-D-Ala (the pentapeptide part II) is studied means Raman optical activity (ROA) spectroscopy. Where for conventiona...

The delta-amino acid 5-aminolevulinic (ALA), is the precursor of endogenous photosensitiser Protoporphyrin IX (PpIX), and currently approved for Photodynamic Therapy (PDT) certain superficial cancers. However, ALA-PDT not very effective in diseases which T-cells play a significant role. Cutaneous T-cell lymphomas (CTCL) group non-Hodgkin malignant diseases, includes mycosis fungoides (MF) Sézar...

introduction: the use of lopinavir/ritonavir (lpv/r) has decreased morbidity and mortality due to human immunodeficiency virus (hiv); however its use could be impaired by hepatotoxicity. therefore, this study was designed to investigate the effects of melatonin (mt) and alpha lipoic acid (ala) on lpv/r-induced hepatotoxicity in male albino rats. methods: rats were divided into groups and treate...

introduction: this study evaluated the effects of pretreatments with melatonin (mt), and alpha lipoic acid (ala) on lopinavir/ritonavir (lpv/r) -induced serum levels of creatinine (cr), urea (u), uric acid (ua) and kidney levels of malondialdehyde (mda), superoxide dismutase (sod), glutathione (gsh) and catalase (cat) in male albino rats. effects of treatments with mt and ala were also evaluate...

background: photodynamic therapy (pdt) is a promising therapeutic modality for the treatment of cancer and other diseases. in this study, the epidermoid carcinoma cell line a431 and the normal fibroblasts were used to investigate whether gold nanoparticles (gnps) can induce an increase in cell death during pdt using 5-aminolevulinic acid (5-ala) as a photosensitizer. methods: human fibroblast a...