Purpose: To study the effect of dexmedetomidine (Dex) on AKTERK signaling pathway and EMT- related proteins in high glucose-induced apoptosis human kidney tubular epithelial cells.
 Methods: HK-2 cells were assigned to control, high-glucose Dex groups. Levels ROS determined using live cell station. Flow cytometry was used measure cycle while Western blot applied assay levels PI3K, A...

The phosphoinositide-3-kinase/Akt (PI3K/AKT) signaling pathway is crucial for Sertoli cell development and completing spermatogenesis. Its main role to promote proliferation inhibit apoptosis. Many factors activate the PI3K/AKT pathway, like hormones, such as follicle stimulating hormone (FSH), androgen, estrogen, insulin name a few. of these have receptors inside or on surface cells (SCs). Thi...

Objective(s): Previous study has indicated that triiodothyronine (T3) facilitated cartilage degeneration in osteoarthritis (OA). This study aimed to investigate the effects of T3 on angiogenesis-related factor expression in human osteoblasts of OA subchondral bone.Materials and Methods: The subchondral bone specimens were obtained from O...

Intracerebroventricular stereptozotocin (STZ) treatment has been described as a suitable model for sporadic Alzheimer’s disease (sAD). Centrally administered STZ decreases insulin and insulin receptors in the brain and interrupts PI3/Akt signaling pathway and GSK-3β. Additionally it raises Bax/Bcl-2 ratio and prompts hippocampal apoptosis. Agmatine, a polyamine derived from L-arginin...

background: the conventional chemotherapeutic regimens which applied for treatment of acute myeloid leukemia (aml) mostly target tumor bulk but not leukemic stem cells (lscs). aberrant expression or activation of mediators such as osteopontin (opn) or pi3k/pten/akt/mtor pathway plays a key role in making prone to develop leukemia. preventing or treating cancer by curcumin (cur) has been suggest...

The purpose of this study was to explore the mechanism Solanine disrupting energy metabolism in human renal cancer ACHN cells and clarify its target. specific method culture cell lines, intervene with high, medium low concentrations. content ATP measured by ELISA method. expression HIF-1α protein PI3K, AKT, p-PI3K, p-AKT PI3K/AKT pathway were detected Western blotting. results showed that compa...

Long-term potentiation (LTP) is a process that certain types of synaptic stimulation lead to a long-lasting enhancement in the strength of synaptic transmission. Studies in recent years indicate the importance of molecular pathways in the development of memory and learning. Tropomyosin receptor kinase B (TrkB) is a member of the neurotrophin receptor tyrosine kinase family, that its ligand is b...

Objective: To investigate the role of KIF3C gene in promoting malignant phenotype lung cancer cells and regulating PI3K/AKT signaling pathway. Methods: CCK-8 transwell assays were used to detect changes cell proliferation migration ability after being transfected with siKIF3C, as well protein expression levels PI3K, p-PI3K, AKT, p-AKT following downregulation by Western blot. Results: The assay...

Background/aim Previous studies have shown that the sandalwood oil constituent α-santalol inhibits growth of cultured human prostate cancer cells in vitro and PC-3 xenografts. Along with from our laboratory, it is well established targets phosphatidylinositol-4,5-bisphosphate 3-kinase-AKT serine/ threonine kinase 1 (AKT) pathway to induce apoptosis but its growth-suppressive effects not been fu...

Objective: Laboratory studies on diabetic rats have shown that diabetic rats have a lower beta cell mass than healthy rats. On the other hand, over the years, with tremendous advances in genetic science, many studies have been done on the expression of genes and its effective factors, such as physical activity. One of these genes is AKT / PKB. Due to the association between the expression of th...