Fetal Akinesia Deformation Sequence (FADS) is a condition characterised by decreased fetal movement (fetal akinesia), multiple joint contractures (arthrogryposis), facial anomalies, intrauterine growth restriction, pulmonary hypoplasia and other developmental abnormalities. These disorders are clinically and genetically heterogenous and its etiology remains unclear. This syndrome is rare and th...

Recent studies, mainly in animals, have shown that the pedunculopontine nucleus (PPN) in the upper brainstem has extensive connections with several motor centres in the CNS. This structure has also been implicated in the akinesia seen in patients with Parkinson's disease. Here we demonstrate that microinjection of gamma-aminobutyric acid (GABA) receptor A antagonist substance, bicuculline, into...

In this study, we investigate the interrelationship between clinical variables and working memory (WM) in Parkinson's disease (PD). Specifically, the aim of the study was to investigate the relationship between disease duration, dopaminergic medication dosage, and motor disability (UPDRS score) with WM in individuals with PD. Accordingly, we recruited three groups of subjects: unmedicated PD pa...

Clinical estimation of the degree of muscular rigidity and akinesia in cases of Parkinson’s disease is difficult, as both produce slowing of voluntary movements. However, while akinesia interferes mainly with the speed at which the movement is initiated following extereoceptive and propioceptive demands, muscular rigidity interferes only with the speed at which a body segment is transferred in ...

OBJECTIVE To compare the effect of sub-Tenon's lidocaine injections (ST) on akinesia and mydriasis to those of systemic atracurium (AT) and retrobulbar lidocaine injections in dogs. ANIMAL STUDIED Ten healthy beagle dogs without apparent ocular disease. PROCEDURES Three treatments were performed on 10 beagle dogs with a minimum 7-day washout period: intravenous injection of AT (0.2 mg/kg, A...

background: it is not clear whether the latest activation sites in the left ventricle (lv) are matched with infracted regions in patients with ischemic cardiomyopathy (icm). we aimed to investigate whether the latest activation sites in the lv are in agreement with the region of akinesia in patients with icm.   methods: data were analyzed in 106 patients (age = 60.5 ± 12.1 y, male = 88.7%) with...

The dopamine system may be involved in three situations: the nigral projection to the basal ganglia, the mesocortical projection to the anterior cingulate gyrus, or the medial forebrain bundle projection to cortical and limbic sites. Because of the close association of dopamine systems with the known neurological syndromes of akinesia, we elected to treat a patient with akinesia due to rupture ...

Introduction Tako-tsubo cardiomyopathy (TCM) is an acute cardiac syndrome with severe hypokinesia of the left ventricle (LV), often affecting the apex causing apical ballooning and heart failure. Sympathetic stress is a trigger of TCM and is probably underdiagnosed and not uncommon in ICU patients [1]. We have developed an experimental rat model of TCM, in which LV apical akinesia develops afte...