Autoimmune neutropenia (AIN), resulting from granulocyte-specific autoantibodies, is much less frequent than other autoimmune hematologic disorders including autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). These autoimmune disorders may precede, synchronize, or follow collagen disorders, viral infections, and lymphoid neoplasms. Herein we present the first case of AIN in a...

Urinary biomarkers of kidney injury are an area of ongoing research in nephrology. For years, urinary eosinophils have been used as biomarkers for acute interstitialnephritis (AIN).Thecharacteristics thatwould make eosinophiluria a useful biomarker for AIN include that (1) eosinophils are consistently present in the urine of patients with AIN (i.e., AIN is characterized by an eosinophilic inter...

The formation of host-guest cyclic architectures, built up through the self-condensation process of [Mo(2)O(2)S(2)](2+) oxothiocations around linear dicarboxylate ions such as adipate (Adip(2-)), suberate (Sub(2-)) and azelaate (Azel(2-)) anions is reported. The complexes [Mo(12)Adip](2-), [Mo(12)Sub](2-) and [Mo(14)Azel](2-) have been characterized in the solid state by X-ray diffraction and i...

OBJECTIVE To evaluate the treatment of anal intraepithelial neoplasia (AIN) with the local immune response modifier imiquimod in human immunodeficiency virus (HIV)-positive men who have sex with men (MSM). DESIGN Prospective, nonrandomized, open-label pilot study, with a mean follow-up time of 9(1/2) months. SETTING Dermatology department of a university hospital. Patients Twenty-eight cons...

AIMS The macroH2A histone variants are epigenetic marks for inactivated chromatin. In this study, we examined the expression of macroH2A2 in anal neoplasm from anal intraepithelial neoplasia (AIN) to anal squamous cell carcinoma (SCC). METHODS AIN and anal SCC samples were analysed for macroH2A2 expression, HIV and human papilloma virus (HPV). The association of macroH2A2 expression with clin...

Background: The etiology and treatment of spontaneous paralysis variants of anterior interosseous nerve (AIN) syndrome remains controversial. Variation and multiple sites of potential compression complicate the successful performance of neurolysis. This anatomic study of the AIN and sites of potential compression in the proximal forearm facilitates critical steps involved in neurolytic procedur...

Urinary biomarkers of kidney injury are an area of ongoing research in nephrology. For years, urinary eosinophils have been used as biomarkers for acute interstitialnephritis (AIN).Thecharacteristics thatwould make eosinophiluria a useful biomarker for AIN include that (1) eosinophils are consistently present in the urine of patients with AIN (i.e., AIN is characterized by an eosinophilic inter...

BACKGROUND Significant variation is reported in the diagnosis of HPV-associated AIN. We previously observed that band-like positivity for p16 in >90% of contiguous cells coupled with Ki67 positivity in >50% of lesional cells is strongly associated with high grade AIN. This study was undertaken to determine if addition of p16 and Ki67 immunostaining would reduce inter- and intraobserver variabil...

For sixteen years, the American Institute of Nutrition Rodent Diets, AIN-76 and AIN-76A, have been used extensively around the world. Because of numerous nutritional and technical problems encountered with the diet during this period, it was revised. Two new formulations were derived: AIN-93G for growth, pregnancy and lactation, and AIN-93M for adult maintenance. Some major differences in the n...

INTRODUCTION Anal intraepithelial neoplasia (AIN), which may be a precursor of anal carcinoma, has been identified on histology following minor anal surgical procedures, in particular the removal of perianal condylomata, in increasing numbers of homosexual and bisexual men. Anal cytology has recently been proposed as a useful method of identifying AIN lesions. OBJECTIVE To compare anal cytolo...