5-HT(2A) serotonin receptors are unusual among G-protein coupled receptors in that they can be internalized and desensitized, in some cell types, in an arrestin-independent manner. The molecular basis of the arrestin-insensitivity of 5-HT(2A) receptors is unknown but is probably caused, in part, by the apparent lack of agonist-induced 5-HT(2A) receptor phosphorylation. Because the arrestin-inse...

A single dose of psilocybin, a psychedelic and serotonin 2A receptor (5-HT2AR) agonist, may be associated with antidepressant effects. The mechanism behind its antidepressive action is unknown but could linked to increased synaptogenesis down-regulation cerebral 5-HT2AR. Here, we investigate if psilocybin changes synaptic vesicle protein (SV2A) 5-HT2AR density in the pig brain. Twenty-four awak...

g -aminobutiric acid (gaba), the major inhibitory neurotransmitter in the central nervous system has two major receptor subtypes (gabaa and gabab). gabab receptors are activated by the antispastic and muscle relaxant agent, baclofen, which is a lipophilic derivative of gaba. since 1962 several strategies have been reported for the synthesis of baclofen.in this study an approach has been made to...

background: prolonged gnrh-a administration in ivf cycles may have some advantages related to the treatment outcomes. objective: in this study, we aimed to analyse the effect of prolonged gonadotropin releasing hormone agonist (gnrh-a) administration on controlled ovarian hyperstimulation outcomes of in vitro fertilization (ivf) patients. materials and methods: in this retrospective study, 55 p...

5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on [198] and subsequently revised [180]) are, with exception of ionotropic 5-HT3 class, GPCRs where endogenous agonist is 5-hydroxytryptamine. The diversity metabotropic increased alternative splicing that produces isoforms 5-HT2A (non-functional), 5-HT2C 5-HT4, 5-HT6 (non-functional) 5-HT7 receptors. Unique amongst GPCRs, RNA...