BACKGROUND/AIMS Infliximab has proven to be effective in the treatment of perianal fistulas in Crohn's disease (CD) but the efficacy of adalimumab is still unclear. The aim of this study is to assess the clinical efficacy of adalimumab and compare the results with those for infliximab. METHODS Forty-seven CD patients treated for perianal fistulas with infliximab from September 2005 to Decembe...

This population-based cross-sectional survey assessed the prevalence of work-aggravated asthma symptoms and the effect of the work environment on the aggravation of symptoms of established asthma. A questionnaire was sent to 2,613 persons (aged 20-65 yrs) with asthma. The analyses were restricted to the 969 respondents who were currently employed. The effect of occupational exposure on the aggr...

A 33 year old woman developed a florid form of chronic active hepatitis after exposure to halothane. Histological and immunological data suggested that autoimmune type chronic active hepatitis antedated the acute hepatotoxic sequelae of the hatothane anaesthesia. Studies on the immuno regulatory functions of peripheral blood lymphocytes revealed a marked defect in suppressor cell function. It i...

OBJECTIVE We assessed associations between parenting a child with autism and stress indicators. METHODS In the 2003 National Survey of Children's Health, parents or other knowledgeable adult respondents for children aged 4 to 17 years reported their recent feelings about their life sacrifices to care for their child, difficulty caring for their child, frustration with their child's actions, a...