Severe alpha1-antitrypsin (AAT) deficiency predisposes to emphysema development. Highly variable rates of decline in lung function are reported in PiZZ individuals. The annual decline in forced expiratory volume in one second (FEV1; delta FEV1) was analysed in relation to smoking status in a cohort of 608 adult PiZZ individuals included in the Swedish national AAT deficiency register. Delta FEV...

Color matches were measured as a function of field diameter (1, 2, 4 and 8 deg) for 53 normal observers aged 13-80 yr. The difference between match midpoints for the 1 deg diameter and the other diameters decreased throughout adulthood, indicating an age-related change in optical density of cone outer segments in the central 1 deg. For all ages, there were large interobserver differences in the...

PURPOSE The purpose of the study was to assess the effect of cigarette smoking on indicators of bone strength across a wide age range, controlling for physical activity and neuromuscular performance. METHODS We conducted a cross-sectional study with 41 smokers (mean age +/- SD, 41.0 +/- 16.1 yr) and 53 nonsmokers (47.5 +/- 18.2 yr) of both sexes. Bone strength indicators (BSI) were assessed i...

Associations among dust exposure, smoking habits, and demographic factors and longitudinal changes of lung function were assessed among male steel workers. Cohort descriptive data analysis was conducted in 541 steel workers who had performed spirometry at least twice between 1982 and 1991 (mean follow-up, 6.1 years). The annual change (slope) in FVC, FEV1, FEV1/FVC%, and in body weight was dete...

FRY, R. J, M., S. LESHER, AND H. I. KOHN. Age effect on cell-transit time in mouse jejunal e$Ywlium. Am. J. Physiol. 20 I (I ) : 213-216. I g6r .Epithelial cell renewal in the jejunum of CAFr mice was studied by observing the time for cells labeled with tritiated thymidine (1.5-2.0 PC/g body wt.) to pass from the crypt to the extrusion zone at the tip of the villus. Mice of three ages were stud...

INTRODUCTION A contributing factor to the loss of muscle mass and strength during aging is the reduction in the number of functioning motor units (MU). It has been shown that lifelong physically active older rats have greater numbers of MU compared with age-matched sedentary controls, suggesting that chronic exercise may preserve MU function with advancing age. This has not previously been exam...

    The length-weight relationship, age, growth parameters, sex ratio, mortality and exploitation rate of Salmo trutta fario were determined in Lar dam. The sex ratio (male: female) was 1:1.84 which differed significantly from the expected 1:1. The length-weight regression was (females) and (males) indicating a negative allometric growth for both sexes. Growth parameters were estimated as L∞ = ...