نتایج جستجو برای: aganglionic
تعداد نتایج: 186 فیلتر نتایج به سال:
The morbid anatomy of Hirschsprung's disease is now firmly established. Swenson and Bill (1948) noted that the dilated colon which figures so largely in the earlier description of the disease terminated at a point proximal to the anus and was followed by a spastic segment. They concluded that the obstruction was due in some way to this segment and that the hypertrophy and dilatation of the bowe...
OBJECTIVES Definite diagnosis of Hirschsprung's disease (HD) is based on histopathological study, but there are limitations associated with standard histology and histochemistry in this regard. The aim of this study was to investigate calretinin immunostaining patterns in both ganglionic and aganglionic HD intestinal specimens and to compare them with control specimens. MATERIALS AND METHODS ...
Congenital hypothyroidism (CH) may present with nonspecific signs and symptoms, though, majority of infants can be asymptomatic. Therefore, understimation and delay in diagnosis may result in severe complications. A 5-month-old female admitted to our clinic with the history of repeated surgical operations due to the diagnosis of congenital aganglionic megacolon. Investigations performed in our ...
Hirschsprung disease (HSCR, aganglionic megacolon) represents the main genetic cause of functional intestinal obstruction with an incidence of 1/5000 live births. This developmental disorder is a neurocristopathy and is characterised by the absence of the enteric ganglia along a variable length of the intestine. In the last decades, the development of surgical approaches has importantly decreas...
showed increased AChE activity. 7 patients ultimately proved to be cases of Hirschsprung's disease; all but one of the rectal biopsies showed an increased AChE activity in the mucosa, and all biopsies showed an increased activity in the submucosa. From the investigation of resected bowel segments it was shown that the strongest activity occurred in the most distal part of the aganglionic bowel ...
Introduction Constipation is one of the most common causes of referral to pediatric gastroenterology clinics. The histopathology and Immunohistochemistry (IHC) studies indicated that several neurons are currently detectable in motility of the gut. We aimed to evaluate calretinin in the children with chronic constipation. Materials and Methods In this cohort study, 40 children with chronic const...
It has been assumed that in piebald lethal mice that develop megacolon, impaired colonic motor activity is restricted to the aganglionic distal colon. Peristaltic mechanical recordings, immunohistochemistry, and quantitative PCR were used to investigate whether regions of the colon, other than the aganglionic segment, may also show anatomical modifications and dysfunctional colonic motor activi...
irschsprung disease is a congenital disorder in Hwhich neurons are missing from the distal bowel. As the enteric nervous system (ENS) is essential for propulsive gut motility, affected infants have intractable constipation. The current treatment for Hirschsprung disease involves surgical removal of the distal aganglionic region and anastomosis of the ganglionic bowel to the anus. Despite this, ...
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