Phagocytosis, intracellular killing of Candida albicans, and superoxide production by rat peritoneal macrophages exposed to aflatoxins B1, B2, G1, G2, B2a, and M1 at several times and concentrations were analyzed to evaluate the intensity of a depressive effect for each mycotoxin. All aflatoxins used at very low concentrations had a depressive effect on the functions of macrophages. The biggest...

Aflatoxins are mainly produced by certain strains of Aspergillus flavus, which are found in diverse agricultural crops. In many lower-income countries, aflatoxins pose serious public health issues since the occurrence of these toxins can be considerably common and even extreme. Aflatoxins can negatively affect health of livestock and poultry due to contaminated feeds. Additionally, they signifi...

In This research, gold nanoparticles were synthesized and functionalized by the antibody of aflatoxins. The quenching of the fluorescence of excitation emission matrices (EEM) of two type of aflatoxins (B1, G1), provoked by the gold nanoparticles, was studied by principal component analysis (PCA) and multivariate curve resolution with alternating least squares (MCR-ALS). These aflatoxins show q...

Aflatoxins difuranocoumarin derivatives are produced by fungi Aspergillus flavus, Aspergil‐ lus parasiticus and Aspergillus nomius [1] and they are part of the group of mycotoxins. From the twenty metabolites that have been formed endogenously in animals, aflatoxins B1, B2, G1 and G2 (AFB1, AFB2, AFG1 and AFG2) are the most common and the most toxic. The names of aflatoxins B1, B2, G1, and G2 a...

Aflatoxins are widely spread mycotoxins produced mainly by Aspergillus species. Consumption of aflatoxin-contaminated foods and drinks causes serious health risks for people worldwide. It is well-known that the reactive epoxide metabolite of aflatoxin B1 (AFB1) forms covalent adducts with serum albumin. However, non-covalent interactions of aflatoxins with human serum albumin (HSA) are poorly c...

Mycotoxins are natural contaminants in raw materials, food and feeds [1]. Aflatoxins are toxic metabolites produced by different species of toxigenic fungi, called mycotoxins. The discovery of aflatoxins dates back to the year 1961 following the severe outbreak of turkey “X” disease, in the England, which resulted in the deaths of more than 100.000 turkeys and other farm animals. The cause of t...

A chemically defined medium giving high yields of aflatoxins has been reported from this laboratory (Reddy, Viswanathan & Venkitasubramanian, 1971). Many workers have studied the incorporation of [ 1J4C]acetate into aflatoxins (Adye & Mateles, I 964; Donkersloot, Hsieh & Mateles, 1968; Detroy & Hesseltine, 1969; Hsieh & Mateles, 1970, 1971). Labelled acetate is efficiently incorporated into afl...

Aflatoxins are a family of toxic, acetate-derived decaketides that arise biosynthetically through polyhydroxyanthraquinone intermediates. Most studies have assumed that aflatoxin B1 is the biosynthetic precursor of the other aflatoxins. We used a strain of Aspergillus flavus which accumulates aflatoxin B2 to investigate the later stages of aflatoxin biosynthesis. This strain produced aflatoxins...

Much research work has been devoted over the last 40 years for developing methods for detection and determination of aflatoxins in foods and agriculture commodities (Chu, 1991; Holcomb, et al., 1992). This effort is continuing and keeping pace with the progress in analytical chemistry. Methods for aflatoxins are required to meet the legislation, monitoring and survey work, and for research. Dif...