AFLATOXIN B1, a carcinogenic metabolite of the fungus Aspergillus flavus, is acutely toxic to a number of species, including rats. Male rats (LD50 7-2 mg./kg.) are more susceptible to the acute oral effects of aflatoxin than are females (LD50 17.9 mg./kg.) (Butler, 1964). Aflatoxin B1 is metabolised to aflatoxin M1 which is present in the blood and urine of dosed rats (Butler and Clifford, 1965...

aflatoxin m1 (afm1) is an important mycotoxin frequently found in milk and dairy products. dairy products and colostrum may be contaminated by aflatoxin m1 when dairy cattle have fed with aflatoxin b1-contaminated feeds. this study was undertaken in a dairy farm around tehran province to determine the presence and level of aflatoxin m1 (afm1) in spray dried and lyophilized colostrum samples. in...

background: aflatoxin m1 (afm1) is a toxic and carcinogenic mycotoxin which after presence in milk and dairy products such as cheese and butter could make them as contaminated food. the main objective of this study was to evaluate the concentration of afm1 in pasteurized and traditional cheese marketed in southern khorasan, from december 2011 to january 2012. methods: a total of 102 cheese samp...

aspergillums can produce and secrete directly afla­toxin m1. during the previous decade several papers pertaining to aflatoxin m1 have been published in different journals. not mention of their more or less scientific aspects, they have fundamentally some problems in different features. in this paper we are going to have a bird's eye view on some articles published on this topic. it is suggeste...

aflatoxin m1 (afm1) is a hydroxylated metabolite of the carcinogen aflatoxin b1 (afb1), and may be found in the milk of lactating animals that have ingested feedstuffs contaminated with afb1 between jun 2010 and march 2011, 149 samples of pasteurized (n=90) and uht (n=59) milk were collected from supermarkets in the cities of shiraz, khuzestan and yazed, iran. all samples were analyzed for afm1...

An electrochemical aptasensor for detection of trace amounts of aflatoxin M1 was developed. This required immobilization of aptamer on screen printed gold electrode comprising of working electrode, counter electrode and reference electrode and was achieved by sequentially layering dithiodipropionic acid, streptavidin and biotinylated-tetraethylene glycol-aptamer. Immobilization of aptamer was m...

mycotoxins are secondary metabolites of molds and have adverse effects on humans, animals, and crops. those can cause illnesses and economic losses. aflatoxin m1 (afm1) is one of the mycotoxins produced from the hydroxylated metabolite of aflatoxin b1 (afb1). it can be found in milk or milk products obtained from livestock that have ingested contaminated feed. in this paper, recent studies were...

aflatoxin m1 (afm1) is the hydroxylated metabolite of aflatoxin b1 (afb1) that it can be found in milk and dairy products. in this study, elisa (enzyme linked immunosorbent assay) technique was used for detection of afm1 in ice-cream in guilan province (northern iran). a total of 90 ice-cream samples was randomly obtained from different supermarkets. in 62 of the 90 ice-cream samples examined (...

Monoclonal antibodies specific for aflatoxin B1, aflatoxin B2, aflatoxin M1, and the major aflatoxin-DNA adducts were obtained following fusion of mouse SP-2 myeloma cells with spleen cells of mice immunized with aflatoxin B1 covalently bound to bovine gamma globulin. The aflatoxin-modified protein used to immunize mice was produced chemically by activating aflatoxin B1 to a 2,3-epoxide derivat...