BACKGROUND Heart disease is one of the most common chronic disease and leading cause of morbidity and mortality worldwide. Adropin, a newly identified protein, is important for energy homeostasis and maintaining insulin sensitivity, and has been referred to as a novel regulator of endothelial cells. Endothelial dysfunction is a key early event in atherogenesis and onset of HD. Therefore, this r...

objective(s):the aim of this study was to evaluate, for the first time, whether the effects of low-dose adropin administration is effective in rats with hyperlipidemia. materials and methods: twenty one wistar albino female rats were randomly divided into 3 groups and fed with high-fat diet for 4 weeks to establish the hyperlipidemia model. meanwhile, adropin was administrated intraperitonealy ...

Water intake reduction (anti-dipsogenic effects) under hypoxia has been well established, but the underlying reason remains unknown. Our previous report indicated that activated TRPV4 neurons in SFO are associated with anti-dipsogenic effects under hypoxia. Although low partial pressure of blood oxygen directly activates TRPV4, humoral factors could also be involved. In the present study, we hy...

BACKGROUND Dyslipidemia, dysregulated adipokine secretion and alteration in glucagon and adropin concentrations are important obesity-related factors in the pathophysiology of human Type 2 diabetes; however, their roles in the pathophysiology of feline diabetes mellitus are relatively unknown. Here, we determined the concentrations of circulating leptin, adiponectin, pro-inflammatory cytokines,...

BACKGROUND Myeloperoxidase (MPO) anti-neutrophil cytoplasm autoantibody (ANCA)-associated vasculitis commonly causes life-threatening pulmonary alveolar hemorrhage or fibrosis. Only a limited number of candidate gene variants have been explored, but hitherto, are not widely confirmed. In the present study, we investigated the importance of energy homeostasis associated gene (Enho) mutations and...

Objective(s):The aim of this study was to evaluate, for the first time, whether the effects of low-dose adropin administration is effective in rats with hyperlipidemia. Materials and Methods: Twenty one Wistar albino female rats were randomly divided into 3 groups and fed with high-fat diet for 4 weeks to establish the hyperlipidemia model. Meanwhile, adropin was administrated intraperitonealy...

Annotation. The study of energy and adipokine metabolism indicators for the development course acute myocardial infarction (AMI) with comorbidity remains relevant. aim was to determine content in patients ST-segment elevation depending on presence absence type 2 diabetes mellitus (DM) after percutaneous coronary intervention (PCI). involved examination 60 AMI (Group 1) 74 2). Each group divided...

Background and aim: Homocysteine adropin effects on endothelial function are antagonistic. The current study aimed to evaluate the association between serum levels of homocysteine severity coronary artery disease (CAD) . Patients methods: This cross-sectional included 86 patients submitted angiography with ≥ 50% stenosis in one or more arteries. Serum Adropin were estimated. anatomical synergy ...