Adrenaline is known to increase in extra-adrenal peripheral organs as well as urine and plasma in the rat after swimming stress. In order to clarify the physiological significance of adrenaline in stress responses, the origin and location of adrenaline in the peripheral organs were examined by measuring adrenaline in the heart, spleen, submaxillary gland and some other organs after adrenalectom...

The role of inflammation has been shown in the pathogenesis of epilepsy, while glucocorticoids and adrenaline have anti-inflammatory effects. The aim of the present study was to investigate the effects of adrenaline, prednisolone, and indomethacin on caffeine-induced epilepsy (epileptiform activity) in rats and to examine the mechanism of the pro-epileptic effect of indomethacin. The adrenalect...

Injectable formulations of L-adrenaline are commonly used in emergency medicine. Despite numerous studies, the comparative contribution and kinetics of the L-adrenaline inactivation pathways during storage have not been conclusively evaluated. We examined the kinetics of L-adrenaline degradation in a prospective study and determined the extent of drug inactivation by different pathways during a...

The purpose of the present study was to investigate the effect of adrenaline on cardiac function parameters. The infusion of adrenaline for induction of stress, its prospective side-effects as well as its effect on left ventricular function were investigated. A clinical examination and echocardiography were performed on 10 healthy horses before and after infusion of adrenaline. During a period ...

OBJECTIVE To assess the efficacy and safety of low dose adrenaline injected subcutaneously to prevent acute adverse reactions to polyspecific antivenom serum in patients admitted to hospital after snake bite. DESIGN Prospective, double blind, randomised, placebo controlled trial. SETTING District general hospital in Sri Lanka. SUBJECTS 105 patients with signs of envenomation after snake b...

To simulate increased sympathoadrenal activity adrenaline was infused in normotensive subjects to achieve plasma adrenaline concentrations similar to those seen after myocardial infarction or hypoglycaemia. Adrenaline was infused after pretreatment for five days with labetalol 200 mg twice daily or placebo given in a random order. The rise in systolic blood pressure and the fall in diastolic bl...

The effect of adrenaline and nor-adrenaline on the spontaneously contracting and quiescent isolated proximal and central pieces of ureters obtained from female (virgin) albino rats of the Sprague Dawley strain were studicd, Adrenaline and nor-adrenaline produced a stimulant effect on the rate and amplitude of the proximal pieces of spontaneously contracting preparations. Both these drugs induce...

Serum gastrin concentrations were measured in patients with duodenal ulcer and controls before, during, and after one-hour intravenous infusion of various doses of adrenaline (0.12 microgram to 6 microgram/min). Gastrin concentrations in the basal state were significantly increased in duodenal ulcer patients compared to controls. The maximal rise in serum gastrin concentrations was obtained at ...

AIM Guidelines for newborn resuscitation state that if the heart rate does not increase despite adequate ventilation and chest compressions, adrenaline administration should be considered. However, controversy exists around the safety and effectiveness of adrenaline in newborn resuscitation. The aim of this review was to summarise a selection of the current knowledge about adrenaline during res...

Stress is a condition that causes steady state in the body to be disrupted. When stressor hits body, hypothalamus will send signal adrenal gland produce catecholamine. One of catecholamines adrenaline. Adrenaline increase heart muscle contraction, dilatation blood vessels, and glycogenolysis gluconeogenesis, increasing glucose. This experimental research with subjects male Rattus norvegicus, 24...