Uncoupling protein-2 (UCP2) is a mitochondrial membrane transporter expressed in white adipose tissue. We observed that circulating adiponectin levels and adiponectin gene expression in adipose tissue are reduced in UCP2-null mice. We studied whether mitochondrial activity and its control by UCP2 may regulate adiponectin gene expression. In 3T3-L1 cells, increasing UCP2 mitochondrial levels by ...

Background: The Indonesian obesity study group examined more than 6000 people from almost all provinces and obtained rates with a body mass index (BMI)> 30 kg / m² in men at 9.16% women 11.02%. Obesity has been known to be associated Adiponectin insulin resistance even an early age. Wiecek (2012) compared adiponectin, lipid proinsulin levels between obese normal adolescents. From these studi...

OBJECTIVE Adiponectin is a unique anti-atherogenic adipocytokine. Regulation of adiponectin secretion is dysfunctional in cardiovascular diseases. The current trial study assessed the effects of omega-3 fatty acids with or without vitamin E on adiponectin gene expression in peripheral blood mononuclear cells and serum adiponectin and adipocyte fatty acid-binding protein (A-FABP; also called ap2...

background the malaysian health and morbidity survey (2006) reported the highest prevalence of type 2 diabetes mellitus (t2dm) among the indian population compared to the malay and chinese populations. many studies have supported the important role of adiponectin in insulin-sensitizing, which is associated with t2dm. these studies have raised a research question whether the variation in prevale...

Low plasma levels of the anti-inflammatory factor adiponectin characterize obesity and insulin resistance. To elucidate the relationship between plasma levels of adiponectin, adiponectin gene expression in adipose tissue, and markers of inflammation, we obtained blood samples, anthropometric measures, and subcutaneous adipose tissue samples from 65 postmenopausal healthy women. Adiponectin plas...

Introduction: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with still growing incidence among adults and young people worldwide. Patients T2DM are more susceptible to develop coronary artery (CAD) than non-diabetic individuals. Several pre-clinical clinical studies suggested that adiponectin, pleiotropic hormone anti-atherogenic, anti-inflammatory, insulin-sensitizing properti...

Background: Adipose tissue is not only an energy storage tissue but also an important endocrine organ that secretes protein hormones. Among them, the production and secretion of adiponectin is inversely correlated to the severity of obesity. In adipose tissue, adiponectin production is transcriptionally regulated by peroxisome proliferator-activated receptor-γ (PPAR-γ). Obesity is a major healt...

OBJECTIVE Breast cancer is the most common type of cancer in women worldwide. It is indicated that increased body mass index elevates the risk of developing breast cancer, worsens prognosis, and decreases survival. Several polymorphisms of adiponectin have been shown to affect serum levels of adiponectin and their association with breast cancer. The aim of this study was to investigate the rela...

Adiponectin is exclusively expressed in adipose tissue and secreted from adipocytes, and shows anti-diabetic and anti-atherogenic properties. However, the precise transcriptional mechanism of adiponectin remains elusive. In this study, the 5' flanking promoter region of human adiponectin gene was analyzed using UCSC genome browser, and a 10 390-bp fragment, containing an evolutionally conserved...

OBJECTIVE Adiponectin is an adipocyte-derived hormone that sensitizes insulin and improves energy metabolism in tissues. This study was designed to investigate the direct regulatory effects of adiponectin on lipid metabolism in adipocytes. RESEARCH DESIGN AND METHODS Basal and hormone-stimulated lipolysis were comparatively analyzed using white adipose tissues or primary adipocytes from adipo...