Extracellular vesicles (EVs) are nanometre-sized released from most cells, including adipocytes. Relatively little is known about adipocyte-derived EVs (ADEVs) in comparison to other EV subtypes, though interest ADEVs as potential paracrine and endocrine communicators of adipose tissue obesity building. Current evidence indicates that contribute the development dysfunction; a key feature obese ...

OBJECTIVES Atherosclerosis is an important risk factor for coronary heart disease. Neuropeptide Y (NPY) and its receptors, located in peripheral tissue such as white adipose tissue, have been linked to obesity and fat storage. The role of NPY in atherosclerosis has not yet been fully studied, so this study was conducted to further investigate the effect of BIIE 0246, an NPY receptor antagonist,...

In mammalian skin, multiple types of resident cells are required to create a functional tissue and support tissue homeostasis and regeneration. The cells that compose the epithelial stem cell niche for skin homeostasis and regeneration are not well defined. Here, we identify adipose precursor cells within the skin and demonstrate that their dynamic regeneration parallels the activation of skin ...

Abstract The specific niche adaptations that facilitate primary disease and Acute Lymphoblastic Leukaemia (ALL) survival after induction chemotherapy remain unclear. Here, we show Bone Marrow (BM) adipocytes dynamically evolve during ALL pathogenesis therapy, transitioning from cellular depletion in the leukaemia to a fully reconstituted state upon remission induction. Functionally, adipocyte n...

BACKGROUND Obesity is associated with increased recurrence and reduced survival of breast cancer. Adipocytes constitute a significant component of breast tissue, yet their role in provisioning metabolic substrates to support breast cancer progression is poorly understood. RESULTS Here, we show that co-culture of breast cancer cells with adipocytes revealed cancer cell-stimulated depletion of ...

Adipose tissue is the primary tissue affected in most single gene forms of severe insulin resistance, and growing evidence has implicated it as a site at which many risk alleles for insulin resistance identified in population-wide studies might exert their effect. There is thus increasing need for human adipocyte models in which to interrogate the function of known and emerging genetic risk var...

After an injury, a timely inflammatory response that involves the recruitment of blood-derived circulating monocytes is essential for tissue repair. Once in wound bed, these cells differentiate into macrophages during phase, process goes awry aging chronic non-healing wounds. Cell differentiation highly energy-demanding process, and metabolic substrates present bed niche are important healing o...

introduction: stromal cells having preadipocyte characteristics can be isolated from adipose tissue, propagated in vitro and induced to differentiate in vitro toward the osteogenic, adipogenic, myogenic and chondrogenic lineages when treated with established lineage-specific factors. in this research we isolated stromal cells from human adipose tissue and cultured and expanded and examined thei...

The development of adipocytes in mice and humans follows a well-defined pathway that commences with a common pluripotent mesenchymal stem cell (MSC), ie., adipogenesis [1]. The early steps of the pathway leading to the generation and the commitment of MSCs to an adipocyte lineage are unknown. Hypothetically, the determination of the fate of MSCs occurs early in cell differentiation (“commitment...