Department of General Surgery, Rambam Medical Center, Haifa, Israel. Ami Mayo, MD, Surgeon; Yoram Kluger, MD, FACS, Chairman; and Associate Clinical Professor of Surgery, Israeli Institute of Technology, and Rappaort School of Medicine. Correspondence: Yoram Kluger, Department of General Surgery, Rambam Medical Center, POB 9602, Haifa, 31096, Israel. [email protected] ADF Health ISS...

Brigadier Jeffrey Rosenfeld joined the Army Reserve in 1984 and is currently Director General Health Reserves – Army. He is Professor and Head of the Department of Surgery at Monash University, and Director of Neurosurgery at the Alfred Hospital. He has served on seven operational deployments to Rwanda, East Timor, Bougainville, the Solomon Islands and Iraq. He has helped to develop and instruc...

This paper summarizes the research performed under DARPA’s Autonomic Distributed Firewalls (ADF) research project. The summary begins with a review of the motivation and objectives of the ADF. Then the architecture and capabilities of the ADF are described, followed by a summary of the operational and technical evaluations of the ADF. The major result of this project is the fact that the core f...

BACKGROUND Alternate day fasting (ADF; ad libitum intake "feed day" alternated with 75% restriction "fast day"), is effective for weight loss, but the safety of the diet has been questioned. Accordingly, this study examined occurrences of adverse events and eating disorder symptoms during ADF. FINDINGS Obese subjects (n = 59) participated in an 8-week ADF protocol where food was provided on t...

Proteins in the actin depolymerizing factor (ADF)/cofilin family are essential for rapid F-actin turnover, and most depolymerize actin in a pH-dependent manner. Complexes of human and plant ADF with F-actin at different pH were examined using electron microscopy and a novel method of image analysis for helical filaments. Although ADF changes the mean twist of actin, we show that it does this by...

A group of231 alfalfa hay sample results received by a commercial lab over 4 years of hay testing in the San Joaquin Valley of California were examined for the relationship between various lab results. ADF2 and NDF were linearly related in this data set (90% of the variation in NDF is explained by the ADF value = R2). There was a very poor relationship between ADF value and CP (R 2 of 26%), whi...

Introduction: Functional Electrical Stimulation (FES) is a technique which can be used to elicit ankle dorsiflexion (ADF). It is used in rehabilitation to improve mobility in patients with multiple sclerosis and stroke. Here we assess the use of concurrent electromyography (EMG) in guiding fMRI analysis so as to improve the detection of activation due to active, passive [1] and electrical-stimu...

The molecular mechanisms by which neurotrophins regulate growth cone motility are not well understood. This study investigated the signaling involved in transducing BDNF-induced increases of filopodial dynamics. Our results indicate that BDNF regulates filopodial length and number through a Rho kinase-dependent mechanism. Additionally, actin depolymerizing factor (ADF)/cofilin activity is neces...

Actin is a regulator of synaptic vesicle mobilization and exocytosis, but little is known about the mechanisms that regulate actin at presynaptic terminals. Genetic data on LIMK1, a negative regulator of actin-depolymerizing proteins of the ADF/cofilin family, suggest a role for ADF/cofilin in presynaptic function. However, synapse physiology is fully preserved upon genetic ablation of ADF in m...

ADF/cofilins are essential regulators of actin filament turnover. Several ADF/cofilin isoforms are found in multicellular organisms, but their biological differences have remained unclear. Here we show that three ADF/cofilins exist in mouse and most likely in all other mammalian species. Northern blot, and in situ hybridization analyses demonstrate that cofilin-1 is expressed in most cell types...