In this study the role of adenosine A1 receptors of the CA1 region of hippocampus on piriform cortex–kindled seizures was investigated in rats. Obtained results showed that in kindled animals, bilateral microinjection of N6–cyclohexyladenosine (CHA), an adenosine A1 receptor agonist, at doses of 10 and 100 mM into the hippocampal CA1 region decreased the afterdischarge duration (ADD), stage 5 s...

introduction: the role of adenosine a1 receptors of the entorhinal cortex on amygdaloid kindled seizures was investigated. material and methods: animals were kindled by daily electrical stimulation of amygdala. in the full kindled animals, n6-cyclohexyladenosine (cha; 0.1, 1 and 10 mm), an adenosine a1 receptor agonist, and 8-cyclopenthyle 1,3-dimethylexanthine (cpt), an adenosine a1 receptor a...

In this study the role of adenosine A1 receptors of the CA1 region of hippocampus on piriform cortex–kindled seizures was investigated in rats. Obtained results showed that in kindled animals, bilateral microinjection of N6–cyclohexyladenosine (CHA), an adenosine A1 receptor agonist, at doses of 10 and 100 mM into the hippocampal CA1 region decreased the afterdischarge duration (ADD), stage 5 s...

Adenosine acts as neuromodulator in the brain, which its involvement in a wide range of brain processes and diseases has been studied, such as epilepsy, sleep, anxiety, panic disorder, Alzheimer’s disease, Parkinson’s disease and schizophrenia. Adenosine receptors have been detected: A1R, A2AR (A2AR), A2BR, and A3R. A1R and A2R inhibit cAMP production, while A2AR and A2BR stimulate cAMP product...

The nucleoside adenosine is present within cells and body fluids of all living organisms and its production, both intra- and extracellularly, is tightly coupled to energy consumption resulting in increased level of extracellular adenosine. The physiological effects of adenosine are mediated through four pharmacologically and biochemically distinct adenosine receptors (AR), i.e. A1, A2A, A2B and...

introduction: activity of the paragigantocellularis (pgi) nucleus located in the rostral ventrolateral medulla is the mediator of dependence, tolerance and withdrawal syndrome. the most important systems which change their activity during morphine consumption include glutaminergic, opioidergicand purinergic (especially adenosine) receptors in the pgi nucleus. however, it has been shown that the...

adenosine acts as neuromodulator in the brain, which its involvement in a wide range of brain processes and diseases has been studied, such as epilepsy, sleep, anxiety, panic disorder, alzheimer’s disease, parkinson’s disease and schizophrenia. adenosine receptors have been detected: a1r, a2ar (a2ar), a2br, and a3r. a1r and a2r inhibit camp production, while a2ar and a2br stimulate camp product...

AzuFluor® 435-DPA-Zn, an azulene fluorophore bearing two zinc( ii )-dipicolylamine receptor motifs, exhibits fluorescence enhancement in the presence of adenosine diphosphate.

it is a well-established fact that adenosine and its receptor subtypes (a 1 and a ) are involved in changes of contractility, heart rate and coronary blood flow (cbf) under different circumstances. this study was conducted to evaluate the role of nitric oxide and prostaglandins in development of these changes. for this purpose, nitro-l-arginine methyl ester (l-name), and indomethacin as inhibit...