نتایج جستجو برای: adenomatous polyps

تعداد نتایج: 17789  

2010
Sharifeh Mehrabi Joyce A Akwe Gregory Adams William Grizzle Xuebiao Yao Felix O Aikhionbare

Colorectal tumors mostly arise from sporadic adenomatous polyps. Polyps are defined as a mass of cells that protrudes into the lumen of the colon. Adenomatous polyps are benign neoplasms that, by definition display some characteristics of dysplasia. It has been shown that polyps were benign tumors which may undergo malignant transformation. Adenomatous polyps have been classified into three his...

2006
Reiping Tang Ann-Joy Cheng Tzu-Chien V. Wang

To investigate the role of telomerase in the multistep Colorectal carcinogenesis, we examined telomerase activity in 31 adenomatous polyps and 22 paired cancer-normal mucosa specimens from non-hereditary nonpolyposis colorectal cancer patients. Telomerase activity was detected in 18% of normal mucosa, 16% of small «1.0 cm) polyps, 20% of intermediate polyps, 71% of large (>2.0 cm) polyps, and ...

Journal: :Cancer prevention research 2011
Harvey J Murff Martha J Shrubsole Zhi Chen Walter E Smalley Heidi Chen Yu Shyr Reid M Ness Wei Zheng

Adenomatous polyps are known precursor lesions for colorectal cancer and some hyperplastic polyps also have malignant potential. The use of aspirin and nonsteroidal anti-inflammatory drugs (NSAID) is associated with a reduced risk of adenomatous polyps; however, less evidence exists with regard to NSAID use and hyperplastic polyp risk. We conducted a colonoscopy-based case-control study includi...

Journal: :Gut 2002
R G Hardy C Tselepis J Hoyland Y Wallis T P Pretlow I Talbot D S A Sanders G Matthews D Morton J A Z Jankowski

BACKGROUND Colorectal adenomatous and, probably, hyperplastic polyp development requires epithelial remodelling and stratification, with loss of E-cadherin expression implicated in adenoma formation. We have shown that P-cadherin, normally expressed in stratified epithelia and placenta, is aberrantly expressed in disturbed epithelial architecture associated with colitis. AIMS (i) To investiga...

2014
Don A. Delker Brett M. McGettigan Priyanka Kanth Stelian Pop Deborah W. Neklason Mary P. Bronner Randall W. Burt Curt H. Hagedorn

BACKGROUND Sessile serrated adenomas/polyps (SSA/Ps) may account for 20-30% of colon cancers. Although large SSA/Ps are generally recognized phenotypically, small (<1 cm) or dysplastic SSA/Ps are difficult to differentiate from hyperplastic or small adenomatous polyps by endoscopy and histopathology. Our aim was to define the comprehensive gene expression phenotype of SSA/Ps to better define th...

2006
T RANZI D CASTAGNONE P VELIO P BIANCHI E E POLLI

Endoscopy with multiple biopsies of the upper gastrointestinal tract was repeated yearly over a two to six year period in nine patients with familial polyposis coli from three families. Adenomatous polyps, one to 20 in number and 2-8 mm in size, were detected in the antrum and the first and second duodenal portions in seven patients, while hyperplastic polyps were detected in four patients in t...

Journal: :Journal of clinical pathology 1987
L R Jarvis P S Graff R Whitehead

Histological sections of adenomatous polyps of the colon showing carcinoma were studied by video image analysis. Nuclear DNA content and morphology were measured in regions identified as either dysplasia, carcinoma confined to the mucosa, or carcinoma invading the muscularis mucosa. Where carcinoma was present, areas of dysplasia in the same polyp were found to have similar distributions of nuc...

Ashraf Mohamadkhani, Maliheh Moradzadeh, Mehrdad Aghaei, Mohammad Hassan Jokar, Sima Sedighi,

Familial adenomatous polyposis is characterized by over 100 colorectal adenomas in the colorectum. The disease equally affects both sexes, with an incidence estimated at 1.14025-1.8300. The disease is premature in people with familial adenomatous polyposis. Patients suffering from familial adenomatous polyposis have a range of extra-intestinal diseases such as papillae, gastric, small intestine...

Journal: :Gastroenterology 2004
Randall W Burt Mark F Leppert Martha L Slattery Wade S Samowitz Lisa N Spirio Richard A Kerber Scott K Kuwada Deborah W Neklason James A Disario Elaine Lyon J Preston Hughes William Y Chey Raymond L White

BACKGROUND & AIMS An attenuated form of familial adenomatous polyposis has been described, but the phenotype remains poorly understood. METHODS We performed genetic testing on 810 individuals from 2 attenuated familial adenomatous polyposis kindreds harboring an identical germline adenomatous polyposis coli gene mutation. Colonoscopy was performed on mutation-positive persons. RESULTS The d...

2016
Feyzullah Uçmak Elif Tuğba Tuncel

BACKGROUND The aim of our study was to evaluate all lesions in the adenoma-dysplasia-cancer sequence of the colon and to examine whether the neutrophil-to-lymphocyte ratio (NLR) can distinguish polyps indicating dysplasia and cancer. MATERIAL AND METHODS A total of 397 patients who had colonoscopic polypectomy between January 2010 and December 2014 were included in our retrospective study. The ...

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