نتایج جستجو برای: adam8 genes

تعداد نتایج: 426378  

2015
Sangeetha Vishweswaraiah Avinash M Veerappa Padukudru A Mahesh Sareh R Jahromi Nallur B. Ramachandra

PURPOSE Asthma is a complex disease caused by interplay of genes and environment on the genome of an individual. Copy number variations (CNVs) are more common compared to the other variations that disrupt genome organization. The effect of CNVs on asthma subgenome has been less studied compared to studies on the other variations. We report the assessments of CNV burden in asthma genes of normal...

2012
Joseph M. Swanson G. Christopher Wood Lijing Xu Lisa E. Tang Bernd Meibohm Ramin Homayouni Martin A. Croce Timothy C. Fabian

BACKGROUND Ventilator-associated pneumonia (VAP) carries significant mortality and morbidity. Predicting which patients will become infected could lead to measures to reduce the incidence of VAP. METHODOLOGY/PRINCIPAL FINDINGS The goal was to begin constructing a model for VAP prediction in critically-injured trauma patients, and to identify differentially expressed genes in patients who go o...

Journal: :Expert Opinion on Therapeutic Targets 2009

Journal: :Nature Reviews Clinical Oncology 2015

Journal: :PLoS ONE 2008
Karine Tremblay Mathieu Lemire Camille Potvin Alexandre Tremblay Gary M. Hunninghake Benjamin A. Raby Thomas J. Hudson Carolina Perez-Iratxeta Miguel A. Andrade-Navarro Catherine Laprise

Asthma is a complex trait for which different strategies have been used to identify its environmental and genetic predisposing factors. Here, we describe a novel methodological approach to select candidate genes for asthma genetic association studies. In this regard, the Genes to Diseases (G2D) computational tool has been used in combination with a genome-wide scan performed in a sub-sample of ...

2008
Shlomo Bakshi Xiang Zhang Sonia Godoy-Tundidor Robert Yuk Sing Cheng Maureen A. Sartor Mario Medvedovic Shuk-Mei Ho

BACKGROUND Cadmium is implicated in prostate carcinogenesis, but its oncogenic action remains unclear. OBJECTIVES In this study we aimed to decipher changes in cell growth and the transcriptome in an immortalized human normal prostate epithelial cell line (NPrEC) following exposure to low-dose Cd. METHODS Synchronized NPrEC cells were exposed to different doses of Cd and assayed for cell vi...

2014
Hae Young Shin Hyosil Kim Min Jung Kwon Dong Hoon Hwang KiYoung Lee Byung Gon Kim

Traumatic spinal cord injury (SCI) often leads to debilitating loss of locomotor function. Neuroplasticity of spinal circuitry underlies some functional recovery and therefore represents a therapeutic target to improve locomotor function following SCI. However, the cellular and molecular mechanisms mediating neuroplasticity below the lesion level are not fully understood. The present study perf...

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