Calmodulin inhibitors enhance cytotoxic effects of doxorubicin (DOX) in DOX-resistant (P388/DOX) P388 mouse leukemia cells by increasing cellular accumulation and retention of drug. In P388/DOX cells treated for 3 hr, cytotoxic effects (based on colony formation in soft agar) of daunorubicin (DAU) in the presence of trifluoperazine (TFP) were DAU concentration-de pendent and enhanced 2to 100-fo...

N-Tnifluoroacetyladniamycin-1 4-valemate(A032) and N-tn fluonoacetyladniamycmn (AD41) have been compared with Adniamycin and daunorubicin in CCRF-CEM human lyrn phoblastic cells. All four agents produce DNA damage, as measured by alkaline. unwinding methods. Thymidine incor poration, a measure of DNA synthesis, is inhibited by AO32 and AO41 and completely blocked by the other drugs. AO32 and AO...

Previous sequencing (1, 2) of human adenovirus type 41 strain Tak (3) DNA only partially identified the regions coding for L4 100K and 33K proteins. These two proteins are involved in vinon morphogenesis (4, 5). We have now completed this identification by cloning an Ad41 3.1 Kb Mstl-EcoRI fragment (map position 64.9% to 74%) in pBluescnptn and sequencing it directly using custom ohgonucleotide...

A total of 57 clam packages that were collected from supermarkets and fish markets from 11 different sites in western Japan between 8 December 2005 and 6 September 2006 were examined for human enteric viruses (i.e., norovirus, Aichi virus, rotavirus, adenovirus, hepatitis A virus, and astrovirus), using PCR and reverse transcription PCR. Sixty-one percent of the packages were contaminated with ...

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Of 35 stool specimens isolated and examined in 293 cells, 15 isolates contained adenovirus species 40 (Ad40), and 4 of these 15 isolates also contained a nonfastidious adenovirus species (Ad1 in two cases, Ad18 or Ad31) which was selected over Ad40 during serial passage in the 293 cells. The selection of Ad1 over Ad40 was examined in detail. Restriction analysis of intracellular DNA and the rel...

The detection of viruses in the sewage of an urban city by nucleic acid amplification techniques allows the identification of the viral strains that are circulating in the community. The aim of the study was the application of such detection which gives useful data on the distribution, spread, and frequency of these viruses, supporting epidemiological studies of the related viral infections. A ...