this article reviews will focus on the concept and formation of micro particles (mps) in circulation and their role in transfusion medicine and immune system. mps are cell membrane derived vesicles which express markers of their parent cells and are found in circulation at low levels. exact functions of mps are unclear. in here, physiological almost all types of circulating mps including platel...

Transfusion is an irreversible event which carries potential benefits as well as risk to the recipient. The objective of this study was to analyse all reported transfusion reactions of the year 2008 in the Blood Bank Unit of Universiti Kebangsaan Malaysia Medical Centre (UKMMC). This is a retrospective study that was carried out by retrieving data from the laboratory information system. A total...

Passive hemagglutination assays (PHA) may be used to detect IgA antibodies to confirm clinical diagnoses of suspected IgA anaphylactic transfusion reactions. Passive hemagglutination inhibition assays (PHIA) may be used to identify IgA-deficient blood donors whose plasma-containing components are transfused to prevent anaphylactic transfusion reactions in prospective recipients at risk because ...

this article reviews will focus on the concept and formation of micro particles (mps) in circulation and their role in transfusion medicine and immune system. mps are cell membrane derived vesicles which express markers of their parent cells and are found in circulation at low levels. exact functions of mps are unclear. in here, physiological almost all types of circulating mps including platel...

Platelet transfusion has been a vital therapeutic approach in patients with hematologic malignancies for close to half a century. Randomized trials show that prophylactic platelet transfusions mitigate bleeding in patients with acute myeloid leukemia. However, even with prophylactic transfusions, as many as 75% of patients, experience hemorrhage. While platelet transfusion efficacy is modest, q...

We provide a comprehensive review of risks associated with allogeneic red blood cell and platelet transfusions in Canada. The review focuses on clinically symptomatic noninfectious transfusion risks (acute and delayed hemolytic, febrile nonhemolytic [FNHTR], allergic, volume overload, transfusion-related acute lung injury, graft-versus-host disease, and posttransfusion purpura) and the risk of ...

Although multiple critical steps are taken to minimize the risk of infection from transfusion of blood or blood products in developed countries, this risk can never be entirely eliminated. In Canada, the risks of noninfectious transfusion reactions, such as transfusion-related acute lung injury and major allergic or anaphylactic reactions, are greater than that of infection. This updated practi...

Although acute non-haemolytic febrile or allergic reactions (ATRs) are a common complication of transfusion and often result in little or no morbidity, prompt recognition and management are essential. The serious hazards of transfusion haemovigilance organisation (SHOT) receives 30-40 reports of anaphylactic reactions each year. Other serious complications of transfusion, such as acute haemolys...

DOI: 10.5581/1516-8484.20110061 Transfusion reactions are complications of blood component transfusions and may be a risk to patients. The risks range from mild urticariform reactions to fatal reactions if not recognized and dealt with promptly. Moreover, with the improvement of serological techniques over the last decades, surveillance of acute reactions has become more and more important as t...