background: the development of toxicity tests regarding toxic responses of different fish species could be more effectively used in predictive toxicology and risk assessment. in this study lethal concentrations (lc50-96 h) values of copper sulphate an important toxic industrial pollutant, on capoeta fusca were determined. behavioral changes at different concentrations of cuso4 were determined f...

acute liver failure (alf) is an uncommon, devastating syndrome of which over 2000 cases occur annually in the usa, with a mortality rate of about 80%. alf is de_ned by the sudden onset of hepatic encephalopathy and coagulopathy (inr_1.5) in an otherwise healthy person. the most common etiologies are acute viral hepatitis a and b, medication overdose (e.g., acetaminophen) and idiosyncratic drug ...

all aquatic organisms are directly or indirectly affected by the physical characteristics of their environment, especially the chemical composition of the water. the high concentration levels, damage tissues and interfere with the normal growth and proliferation. the aim of this research was to investigation acute toxicity of znso4 and cucl2 to gambusia holbrooki by static bioassays at differen...

the aqueous and ethanolic extracts of pedalium murex (pedaliaceae) was investigated for antipyretic activity in rats using brewer’s yeast-induced pyrexia models. brewer’s yeast (15%) was used to induce pyrexia in rats. both the extract (200 and 400 mg/kg body weight p.o produced a significant (p

the effects of hydroalcoholic extract (he) of curculigo orchioides gaertn. rhizome (hypoxidaceae) and its alkaloidal and non-alkaloidal fractions (af) and (naf) were evaluated in carrageenan-induced paw edema experimental models of inflammation. the oral administration of he, their af and naf fractions were used at doses of 100, 300 and 500 mg/kg. the effect produced by the he, af and naf fract...

Acute systemic toxicity studies are carried out in many sectors in which synthetic chemicals are manufactured or used and are among the most criticized of all toxicology tests on both scientific and ethical grounds. A review of the drivers for acute toxicity testing within the pharmaceutical industry led to a paradigm shift whereby in vivo acute toxicity data are no longer routinely required in...

Teucrium Polium L. (TP) is widely used in traditional medicine of many countries including Iran. There are various reports about pharmacological properties of TP such as calcium antagonist, anti- ulcer, anti – diabetic. There are a few reports about possible toxicological effects of this plant. In the present study we designed to evaluate the subchronic toxicity of Teucrium Polium total extract...

Objective(s) Ocimum basilicum L. is widely used in folk medicine of many countries including Iran. Both O. basilicum and its oil extract have received considerable attention for their potential medicinal properties, but there are a few reports about possible toxicity of this plant. Therefore, in the present study, acute and subchronic toxicity of O. basilicum hydroalcohlic extract have been ev...

Teucrium Polium L. (TP) is widely used in traditional medicine of many countries including Iran. There are various reports about pharmacological properties of TP such as calcium antagonist, anti- ulcer, anti – diabetic. There are a few reports about possible toxicological effects of this plant. In the present study we designed to evaluate the subchronic toxicity of Teucrium Polium total extract...

the effects of chronic administration of lithium, on acute toxicity of chlorpromazine (cpz) in male albino mice was studied and the ldso values were determined from dose-probit curves. tfie results showed that in lithium pretrealed animals (anmials consumed drinking water containing 600mg/l lithium chloride for 10 days) the ld50 value (the dose corresponding to probit 5) of cpz increased signif...