BACKGROUND Several large, randomized clinical trials have shown that early thrombolytic therapy substantially reduces early mortality after acute myocardial infarction (MI). In most trials, eligibility criteria include typical chest pain and diagnostic ST segment elevation in two or more contiguous leads of the standard 12-lead ECG. Unfortunately, large areas of the thoracic surface are left un...

There are currently almost no genetic data associated with the acute coronary syndromes of unstable angina or myocardial infarction (MI). The only documented genetic variants associated with increased risk for MI, per se, are the A and B blood group variants. There are no genetic data differentially associated with ST segment elevation MI or non-ST segment elevation MI. Genetic variants predisp...

background: studies on the prognosis of st elevation myocardial infarction (stemi) versus non-st elevation myocardial infarction (non-stemi) have shown different results. the present study was designed to compare the early outcome and left ventricular systolic function of patients with st and non-st elevation myocardial infarction. methods: the patients' information was derived from 10,065 cons...

S everal prior studies have shown that patients with diabetes mellitus have worse in-hospital outcomes compared to non-diabetic patients when admitted for an acute myocardial infarction (MI). 2 Few studies have examined this same issue among patients admitted across the entire spectrum of acute coronary syndromes (ACS) (unstable angina, non-ST elevation MI, ST elevation MI). 4 Since patients ad...

The term, acute coronary syndrome (ACS), describes a spectrum of clinical conditions ranging from ST-segment elevation myocardial infarction (STEMI) to non–ST-segment elevation MI (N–STEMI) and unstable angina (UA) (Fig. 119.1) (1). These manifestations of acute myocardial ischemia may revert to the presymptomatic state or evolve into a non-Q wave (also termed nontransmural) MI or to Q wave (or...

ventricular MI suppresses this ST segment elevation in the precordial leads and yields an ST segment elevation in leads II, III, and aVF.2-4 Massive STsegment elevation in precordial and inferior leads in RVMI has also been observed but is extremely rare.5 Thus, ST elevation in precordial leads should not exclude an infarction of the right ventricle that demands a treatment different from that ...

Although thrombolytic therapy has been a major advance in the treatment of acute ST-segment elevation myocardial infarction (MI), new thrombolytic agents have been unable to improve early reperfusion. Because aspirin has been shown to be a very effective adjunctive agent in patients with acute MI, it has been hypothesized that the use of platelet glycoprotein (GP) IIb/IIIa receptor inhibitors c...

Dual antiplatelet therapy with aspirin and a thienopyridine drug that blocks the platelet adenosine diphosphate receptor P2Y12 is the cornerstone of management in patients presenting with acute coronary syndrome (ACS). Clopidogrel is the most widely used thienopyridine, with evidence of benefit in non–ST-elevation myocardial infarction (MI),1 percutaneous coronary intervention (PCI),2 and ST-el...

OBJECTIVES We sought to investigate the short-term prognostic value of the admission electrocardiogram (ECG) in patients with a first acute myocardial infarction (MI) without ST segment elevation. BACKGROUND ST segment depression on hospital admission predicts a worse outcome in patients with a first acute MI, but the prognostic information provided by the location of ST segment depression re...