BACKGROUND Vaccines including conserved antigens from Streptococcus pneumoniae and nontypeable Haemophilus influenzae (NTHi) have the potential to reduce the burden of acute otitis media. Little is known about the antibody response to such antigens in young children with recurrent acute otitis media, however, it has been suggested antibody production may be impaired in these children. METHODS...

To assess the relation between early acute otitis media and exposure to respiratory pathogens mediated by siblings and other children, a prospective cohort of 3754 Norwegian children born in 1992-3 was followed up from birth to 12 months. Of these, 25% had one or more episodes of acute otitis media during the first year. Results from multiple logistic regression analysis adjusted for confoundin...

In an open-label study, the concentrations of azithromycin in middle ear effusions and plasma were determined in 29 children between 1 and 8 years of age with a diagnosis of either secretory otitis media of at least 1 month's duration or acute otitis media. Azithromycin (10 mg/kg) was administered as a single dose 12, 24 or 48 h before the insertion of tympanostomy tubes to 17 children with sec...

Acute otitis media is usually considered a simple bacterial infection that is treated with antibiotics. However, ample evidence derived from studies ranging from animal experiments to extensive clinical trials supports a crucial role for respiratory viruses in the etiology and pathogenesis of acute otitis media. Viral infection of the upper respiratory mucosa initiates the whole cascade of even...

'Trcatmcnt of' acut o)titis media: a controlled studv of 142 childrcn. (an .lled.Assoc7 197(;102:263-. 5 Halstcd C. Ilcpow MI. Balassaniati N, Eimmerich J, \\olinskv E. Otitis mcdia: clinical observations, microbiology, and evaluation of therapy. .lmIDisChild 1968;115:542-51. 6 Howie VM, I'loussard JH. Efficacy ot' fixed combinationi antibiotics versus separate conmponents in otitis media. Clin...

This report presents the results of the clinical observation of 96 children under ten years of age with acute otitis media (107 ears) who visited our out-patient clinic from May 1986 to August 1987. The patients were classified into the following three groups according to clinical course: Group 1: 25 cases (26.0%) in which acute inflammatory findings rapidly disappeared and otitis media was cur...

BACKGROUND A systematic quantitative review was conducted of evidence relating parental smoking to acute otitis media, recurrent otitis media, middle ear effusion, and adenoidectomy and/or tonsillectomy. METHODS Forty five relevant publications were identified after consideration of 692 articles selected by electronic search of the Embase and Medline databases using keywords relevant to passi...

OBJECTIVES To estimate the occurrence of and associations between upper respiratory tract infections in preschool children, and to assess constitutional and environmental factors as determinants of these infections. DESIGN Population-based cross-sectional study. SETTING Oslo, Norway. PARTICIPANTS Preschool children, aged 4 to 5 years (3853 completed questionnaires). MAIN OUTCOME MEASURE...

BACKGROUND Acute myringitis is an inflammation of the tympanic membrane that occurs alone or in association with external otitis or otitis media. The two clinical entities, based on physical examination, are bullous myringitis and hemorrhagic myringitis. OBJECTIVES To investigate the association of concomitant middle ear disease with acute myringitis and to analyze the bacteriologic findings ...

Bacteria Isolated from Otitis Media with Effusion in Children, Shiraz, Iran. Iran J Med Sci 2011;36 (4):273–80. 49. Šprem N, Pegan B, Glunčić I. Otologija. Bumber Ž, Katić V, Nikšić-Ivančić M i sur. Otorinolaringologija. Zagreb: Naklada Ljevak; 2004, str. 32–47. 50. Šprem N. Otologija. Krajina Z i sur. Dječja otorinolaringologija. Zagreb: Školska knjiga; 1998, str. 122–158. 51. Y Woo-Lee, Y Chu...