Complete data regarding age, sex, karyotype, and French-American-British Cooperative Group classification were available for 239 unselected patients with acute nonlymphocytic leukemia. Of these, 128 were classified as having acute myeloblastic leukemia (M1 or M2); within the acute myeloblastic leukemia group, 83 (65%) of the patients were chromosomally abnormal. Except for 16 patients with a t(...

background: the wilm’s tumor gene 1 (wt1) encodes a zinc finger transcription factor that is inactivated in a subset of wilm’s tumors. it plays a crucial role in growth, proliferation and development of some embryonic and adult organs. wt1 is expressed as a tumor associated antigen (taa) in various types of solid and hematopoietic malignancies and can be employed as a useful marker for targeted...

Primary myelofibrosis (PMF) is a disease from the group of Ph–negative myeloproliferative tumors, which characterized by bone marrow fibrosis, splenomegaly and extramedullary hematopoiesis. The mean life in PMF ranges 7.6 to 10 years varies widely depending on appearance additional mutations higher degree malignancy. Most patients have an indolent flow, some with PMF, progresses rapidly develop...

INTRODUCTION Modern therapy makes it possible for 60-80% patients with acute myeloid leukemia to achieve complete remission after induction therapy. However, most of them will relapse within six months to a year without additional cytostatic therapy. The questions regarding post-remission therapy remain unanswered. The objective of this study was to compare the survival and relapse rate among t...

patients with acute myeloblastic leukemia (aml) with monosomy 7 are a group of patients with refractory aml who have a very poor prognosis. therefore, rationally designed new therapies, including metronomic chemotherapy regimen with histidine deacetylase inhibitors (valporic acid, atra) are being investigated as potential treatments for the population of refractory cases of aml. herein, we repo...

We tested serial bone-marrow samples from 47 adults with acute myeloblastic leukemia in remission for reactivity with heteroantiserums to leukemia-associated antigens, to determine whether imminent relapse could be detected in patients with acute leukemia. Of 26 patients who relapsed by standard morphologic criteria, 21 had increased immunoreactivity of bone marrow for one to six months (mean, ...

Fifteen cases (3.1%) of localized myeloblastic tumors occurring among 478 patients with acute granulocytic leukemia (AG 1) and chronic granulocytic leukemia (CGL) are described. The majority of tumors were discovered at autopsy. Numerous cases of chloroma associated with AG L have been reported; however, in this series, the incidence of myeloblastic tumors in CGL was twice as high. The importan...