Acute Mania Quetiapine XR (FDA approved for the treatment of acute mania) monotherapy has been shown to be more effective than placebo in treating acute mania with improvement starting at day 4. Aripiprazole adjunctive therapy was more effective than placebo adjunctive therapy in treating manic symptoms in BD manic patients with inadequate response to lithium or divalproex in a 6 week trial. Ol...

objective: the purpose of this study was to evaluate the effect of adjunctive topiramate in treating acute mania. methods: in this study which was a double-blinded randomized clinical trial, 46 bipolar patients in manic episode, were treated with lithium carbonate and topiramate versus lithium carbonate and placebo and treatment responses were assessed by young mania rating scale (ymrs) weekly....

In an open trial on manic patients, side-effects of carbamazepine, lithium and haloperidol were evaluated weekly over a 4-week period. The total side-effects with the three drugs were not significantly different, but the rate of amelioration of the same was best for lithium and least for haloperidol. It was indicative that lithium was better tolerated drug than the other two.

BACKGROUND Anecdotal reports suggests that most clinicians treat medications as belonging to a class with regard to all therapeutic indications; this means that the whole 'class' of drugs is considered to possesses a specific therapeutic action. The present article explores the possible existence of a true 'class effect' for agents available for the treatment of bipolar disorder. METHODS We r...

Mania following or associated with medical and pharmacological conditions is well known. However there are no reports of mania in a case of acute viral hepatitis B infection. This paper describes a manic disorder in a young female with acute viral hepatitis B infection, without any past or family history of psychiatric illness or associated psychosocial stressors.

Atypical antipsychotic medications are widely used for the treatment of bipolar disorder. Most empirical support suggests that these medications are efficacious in the treatment of acute mania, but there is considerably less support for the utility of these drugs in other phases of bipolar disorder. However, it is likely that several of these drugs will demonstrate efficacy in relapse preventio...

Herpes simplex encephalitis is associated with marked psychological disturbances both in the acute phase and as a chronic sequelae. Mania has been reported as an acute phase manifestation of HSE, but not as long term consequence. Here we report two cases of mania developing as a long term complication of HSE, in the absence of any other predisposing factor. The possible mechanisms underlying th...