Acute lymphocytic leukemia (ALL) is one of the frequent malignancies in pediatrics and involves bone marrow and extramedullary sites. Proptosis as extramedullary involvement of leukemia usually present in acute and chronic myeloid leukemia. It is extremely rare for ALL to present initially as proptosis.Here, a-21-month-old boy was presented with proptosis without any associated symptoms except ...

chromatin-associated DNA-directed DNA polymerase activity, and the soluble RNase-sensitive endogenous DNA polymerase activity were examined in two fibroblast cell lines (WI-38 and WI-38VA13), in thirteen lymphoid cell lines originated from normal persons or from acute lymphocytic leukemia, acute myelocytic leukemia, Burkitt lymphoma, or multiple myeloma patients, and also in cells obtained dire...

lowed by determination of radioactivity in respiratory COj, protein, lipids, organic acids, and free amino acids. The greatest quantitative and qualitative changes in asparagine metabolism were found in lymphosarcoma with leukemic blood picture. Chronic lymphocytic leukemia resembled the normal pattern with acute lymphocytic leukemia occupying an intermediate position. With pro gression of chro...

Nitric oxide (NO) is a molecule required for many physiological functions, produced from L-arginine by NO synthases (NOS). It is a free radical, producing many reactive intermediates that account for its bioactivity. Sustained induction of the inducible form of NOS (iNOS) in chronic inflammation may be mutagenic, through NO-mediated DNA damage or hindrance to DNA repair, and thus potentially ca...

The sialic acid content of erythrocytes from healthy individuals of different blood types and of patients with known hematological disorders has been determined. The sialic acid was completely released enzymatically with sialidase and quantitated by the thiobarbituric acid method. The sialic acid content of erythrocytes was constant irrespective of ABO blood type, or anticoagulant used; viz, 0....

Nitric oxide (NO) is a molecule required for many physiological functions, produced from L-arginine by NO synthases (NOS). It is a free radical, producing many reactive intermediates that account for its bioactivity. Sustained induction of the inducible form of NOS (iNOS) in chronic inflammation may be mutagenic, through NO-mediated DNA damage or hindrance to DNA repair, and thus potentially ca...

Tumor cells obtained from leukemia and lymphoma patients were investigated for specific insulin receptors. Using radioactive 125I-labeled insulin, specific insulin binding sites were demonstrated on most acute lymphocytic leukemia (ALL) and acute myelocytic leukemia (AML) cells, including acute promyelocytic leukemia (APL), chronic myelocytic leukemia (CML), and acute monocytic leukemia (AMoL) ...

background : acute lymphocytic leukemia is one of the common cancers of childhood and currently, 80 percent of these children survive more than 5 years by getting the right treatment. since long-term treatment is painful and invasive, preventing the side effects and their influence on quality of life is an important issue which introduces consideration for self-care. consequently, the present s...

allogeneic hematopoietic stem cell transplantation (hsct) is the most effective therapy to prevent relapse in acute lymphocytic leukemia (all). this benefit is affected by non-relapse mortality (nrm) due to complications such as graft versus host disease (gvhd). a new approach in analyzing time-dependent covariates in competing risks is landmark analysis. so, the aim of this study is to evaluat...