Richter's transformation of chronic lymphocytic leukaemia (CLL) to high-grade B-cell Non-Hodgkin lymphoma occurs in < 5% of CLL cases. Transformation of CLL to Hodgkin Lymphoma is a much rarer event and here we describe a patient who developed Richter's transformation into a Hodgkin Lymphoma presenting as rapidly progressive hepatosplenomegaly.

it has recently been shown that ror1, a member of the receptor tyrosine kinase family, is overexpressed in leukemic b cells of chronic lymphocytic leukemia (cll) and a subset of acute lymphoblastic leukemia (all). in this comparative study the expression profile of ror1 mrna was investigated in iranian patients with cll and acute myelogenous leukemia (aml) and the results were compared with tho...

background among all pediatric cancers acute lymphoblastic leukemia (all) is highly prevalent, butthe overall cost of all management is not well-known, there is a need to assess the berlin-frankfurt-munster (bfm) protocol commonly used in all management in iran. so, the aim of this study was to estimate direct and indirect costs of all treatment among children based on the all-bfm protocol from...

BACKGROUND The use of occupational cohort studies to assess the association of benzene and lymphoma is complicated by problems with exposure misclassification, outcome classification, and low statistical power. OBJECTIVE We performed meta-analyses of occupational cohort studies for five different lymphoma categories: Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), multiple myeloma (MM), ac...

introduction: osteoprotegerin (opg), a soluble decoy receptor secreted by osteoblasts, binds rank-l, preventing stimulation of osteoclastogenesis. in the present study we aimed to investigate the impact of opg variants and susceptibility to childhood acute lymphocytic leukemia (all) in a sample of iranian population. methods: this case-control study was done on 98 all and 124 healthy children. ...

300 Letters to the Editor Table 1. Diagnostic criteria for Wladenström's macroglobulinemia and IgM monoclonal gammopathy of undetermined significance. Wladenström's macroglobulinemia a) IgM monoclonal gammopathy of any entity b) Lymphomatous bone marrow infiltration by lymphocytes with clonal plasmacytoid differentiation c) Intertrabecular bone marrow infiltration d) Immunophenotype lymphoplasm...

Histologic transformation (HT) refers to a biologic event leading to the development of a high-grade, aggressive non-Hodgkin lymphoma in patientswith anunderlying follicular lymphoma (FL). Transformation to diffuse large B-cell lymphoma (DLBCL) or Burkitt lymphoma is also known to take place in other subtypes of indolent lymphoma such as marginal zone lymphoma, lymphoplasmacytic lymphoma, small...

calcium metabolic disorders, such as hypercalcemia is a potentially life-threatening disorder especially when coupled with an already compromised condition. the aim of this study was to determine the prevalence of metabolic calcium disorders in childhood cancers of patients admitted to the pediatric ward of vali-asr hospital from the year 2001-2008. the study was carried out by reviewing hospit...

Numb chin syndrome is a rare sensory neuropathy of the mental nerve characterized by numbness, hypoesthesia, paraesthesia, and very rarely pain. Dental causes, especially iatrogenic ones, maxillofacial trauma, or malignant neoplasm are etiologic factors for this rare syndrome. Many malignant and metastatic neoplasms are causing this syndrome, like primary osteosarcoma, squamous cell carcinoma, ...

Large cell lymphomas and Hodgkin disease may develop during the course of chronic lymphocytic leukemia (CLL). In some cases the transformed cells are Epstein-Barr virus (EBV)-positive and not clonally related to the CLL cells. In other cases the transformed cells have the same clonal rearrangements as the CLL cells. Here we describe a composite lymphoma in a patient with CLL that exhibits a com...