Acute glomerulonephritis (AGN) remains fairly common in the developing world although its frequency has declined in the industrial countries. The pattern of AGN was studied in one hundred hospitalised children. We recorded an increased prevalence in school age, i.e., 6-15 years (75%) and the occurrence of a streptococcal infection (90%), most often a pharyngeal infection (86%), one to three wee...

Karsner (1908) described 'congenital nephritis' in an infant who died 45 minutes after a normal birth, and Lapage (1932) discussed acute haemorrhagic nephritis in an 11-day-old boy who died in a few days. Conrad (1938) gave a resume of three infants with neonatal nephritis for which no cause was found. One infant died on the seventh day of life, but the others recovered. Generalized oedema, hae...

Kidney tissue from 97 patients was studied by immunofluorescent techniques using antiserum to purified properdin. All patients with acute poststreptococcal glomerulonephritis showed deposition of properdin and the third component of complement (C3), either as "humps" on the basement membrane, or in the mesangium. In all cases of chronic membranoproliferative glomerulonephritis, properdin and C3...

The C1q solid phase and Raji cell radioimmune assays were used to determine the frequency of detectable circulating immune complexes in patients with glomerulonephritis. In this study, 46% of 56 patients with glomerulonephritis had evidence of circulating immune complexes. More important, circulating immune complexes were associated with some, but not other, types of glomerulonephritis. Thus, i...

The assessment of disease incidence in Uganda, an emerging but still young country, presents many problems. Information about a disorder such as acute glomerulonephritis, which has a high spontaneous recovery rate and may present atypical clincal features, is particularly liable to be misleading. The evidence that already exists is conflicting. Luder (1958) saw no cases of 'Type I' nephritis in...

A four-year old boy was admitted to the hospital due to acute thrombocytopenic purpura. Three days later he developed edema, hematuria and hypertension. The diagnosis of acute poststreptococcal glomerulonephritis was based upon the evidence of previous sore throat, hypocomplementemia and increased antistreptolysin O titer. Renal biopsy was contraindicated due to throbocytopenia. An extensive wo...

Acute glomerulonephritis, essentially a disease of child hood that accounts for 90% of renal disorders in children. Acute glomerulonephritis (AGN) is a disease characterized by the sudden appearance of edema, hematuria, proteinuria, and hypertension. There is wide vari-ability in manifestations and course of the disease where they do not predict the out come. Hence this study was undertaken to ...