Acetylcholinesterase (AchE) is a large glycoprotein that, aside from its known cholinolytic activity, co-exists with other transmitter systems and possesses other functions. In the present study, the effects of short-term rapid-eye-movement sleep deprivation (REM-SD) on AchE activity in the anterior hypothalamic area have been investigated. Using the flower-pot method, adult male albino ra...

ATONIA OF SKELETAL MUSCLES IS ONE OF THE CARDINAL FEATURES OF RAPID EYE MOVEMENT (REM) SLEEP. Superimposed on this atonia is intermittent activity in both axial and limb muscles. REM sleep behavior disorder (RBD) is characterized by excessive motor activity during REM sleep with acting out of dreams.1 The diagnosis of RBD is made by the appearance of elevated submental electromyogram (EMG) tone...

STUDY OBJECTIVE Examine the effects of donepezil on sleep and rapid eye movement (REM) sleep electroencephalogram (EEG) in patients with Alzheimer disease, using polysomnography, and the correlation between REM sleep EEG parameters and cognitive scores. DESIGN Randomized, double-blind, placebo-controlled design. SETTINGS Two sleep research centers, University Hospital. PARTICIPANTS Thirty...

Crump, Shawn M., Robert N. Correll, Elizabeth A. Schroder, William C. Lester, Brian S. Finlin, Douglas A. Andres, and Jonathan Satin. L-type calcium channel -subunit and protein kinase inhibitors modulate Rem-mediated regulation of current. Am J Physiol Heart Circ Physiol 291: H1959–H1971, 2006. First published April 28, 2006; doi:10.1152/ajpheart.00956.2005.—Cardiac voltage-gated L-type Ca cha...

acetylcholinesterase (ache) is a large glycoprotein that, aside from its known cholinolytic activity, co-exists with other transmitter systems and possesses other functions. in the present study, the effects of short-term rapid-eye-movement sleep deprivation (rem-sd) on ache activity in the anterior hypothalamic area have been investigated. using the flower-pot method, adult male albino rats we...

The developmental decrease in rapid-eye-movement (REM) sleep in man occurs between birth and after puberty. We hypothesize that if this decrease in REM sleep does not occur, lifelong increases in REM sleep drive may ensue. Such disorders are characterized by hypervigilance and sensory-gating deficits, such as are present in postpubertal onset disorders like schizophrenia, panic attacks (a form ...

Cardiac voltage-gated L-type Ca channels (Ca(V)) are multiprotein complexes, including accessory subunits such as Ca(V)beta2 that increase current expression. Recently, members of the Rad and Gem/Kir-related family of small GTPases have been shown to decrease current, although the mechanism remains poorly defined. In this study, we evaluated the contribution of the L-type Ca channel alpha-subun...

Rapid eye movement sleep in males is characterized by penile erection along with EEG desynchronization, muscle atonia, ponto-geniculo-occipital waves, and rapid eye movements (REM). The central neural mechanisms regulating sleep related erections (SREs) are not known. Recently, the lateral preoptic area has been shown to contribute in sleep-related erectile mechanisms. The present study was con...

Ligands acting at the benzodiazepine (BZ) site of g-aminobutyric acid type A (GABAA) receptors currently are the most widely used hypnotics. BZs such as diazepam (Dz) potentiate GABAA receptor activation. To determine the GABAA receptor subtypes that mediate the hypnotic action of Dz wild-type mice and mice that harbor Dz-insensitive a1 GABAA receptors [a1 (H101R) mice] were compared. Sleep lat...